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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2018
In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes
In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes
Autor:innen
Herausgeber
Quelle
Journal of Toxicology and Environmental Health
81, Heft 13, 1 Onlineressource (Pages 589-603)
81, Heft 13, 1 Onlineressource (Pages 589-603)
Schlagwörter
Zitation
LEME, Daniela Morais, Tamara GRUMMT und Andrea SEHR, 2018. In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes. Journal of Toxicology and Environmental Health [online]. 2018. Bd. 81, Heft 13, 1 Onlineressource (Pages 589-603). DOI 10.60810/openumwelt-266. Verfügbar unter: https://openumwelt.de/handle/123456789/5509
Zusammenfassung englisch
Several synthetic dyes are used by textile industry for supplying the market of colored clothes. However, these chemicals have been associated with a variety of adverse human health effects, including textile dermatitis. Thus, there is a growing concern to identify textile dyes potentially as skin immunotoxicants. The aim of this in vitro study was to characterize the immunotoxic potential of reactive (Reactive Green 19 [RG19], Reactive Blue 2 [RB2], Reactive Black 5 [RB5]) and disperse (Disperse Red 1 [DR1]) textile dyes using a dermal cell line. For this purpose, a cell-based approach was conducted with immortalized human keratinocytes (KC) (HaCaT) using selected biomarkers of cutaneous inflammation including modulation of matrix metalloproteinases (MMP), oxidative stress such as reactive oxygen species (ROS) generation, and inflammatory cytokine profile. DR1 was the only dye able to trigger an immune response such as release of IL-12 cytokine, a potent co-stimulator of T helper 1 cell, which may be considered as a skin immunotoxicant. The reactive dyes including RB5 that were previously reported as skin sensitizers failed to induce inflammatory reactions under the conditions tested. The reactive dyes studied may pose a risk to human KC by induction of effects related to modulation of MMP-2 (RB5) and -9 (RB5 and RB2) and generation of ROS (RG19 and RB2). Thus, all these dyes need to be used with caution to avoid undesirable effects to consumers who may be exposed dermally. Quelle: https://www.tandfonline.com