Publikation:
In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes

Kurzanzeige
dc.contributor.authorLeme, Daniela Morais
dc.contributor.authorGrummt, Tamara
dc.contributor.authorSehr, Andrea
dc.date.accessioned2024-06-16T14:52:14Z
dc.date.available2024-06-16T14:52:14Z
dc.date.issued2018
dc.description.abstractSeveral synthetic dyes are used by textile industry for supplying the market of colored clothes. However, these chemicals have been associated with a variety of adverse human health effects, including textile dermatitis. Thus, there is a growing concern to identify textile dyes potentially as skin immunotoxicants. The aim of this in vitro study was to characterize the immunotoxic potential of reactive (Reactive Green 19 [RG19], Reactive Blue 2 [RB2], Reactive Black 5 [RB5]) and disperse (Disperse Red 1 [DR1]) textile dyes using a dermal cell line. For this purpose, a cell-based approach was conducted with immortalized human keratinocytes (KC) (HaCaT) using selected biomarkers of cutaneous inflammation including modulation of matrix metalloproteinases (MMP), oxidative stress such as reactive oxygen species (ROS) generation, and inflammatory cytokine profile. DR1 was the only dye able to trigger an immune response such as release of IL-12 cytokine, a potent co-stimulator of T helper 1 cell, which may be considered as a skin immunotoxicant. The reactive dyes including RB5 that were previously reported as skin sensitizers failed to induce inflammatory reactions under the conditions tested. The reactive dyes studied may pose a risk to human KC by induction of effects related to modulation of MMP-2 (RB5) and -9 (RB5 and RB2) and generation of ROS (RG19 and RB2). Thus, all these dyes need to be used with caution to avoid undesirable effects to consumers who may be exposed dermally. Quelle: https://www.tandfonline.comen
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-266
dc.identifier.urihttps://openumwelt.de/handle/123456789/5509
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleIn vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleJournal of Toxicology and Environmental Health
local.bibliographicCitation.originalDOI10.1080/15287394.2018.1464981
local.bibliographicCitation.volume81, Heft 13, 1 Onlineressource (Pages 589-603)
local.collectionAufsätze
local.contributor.authorId02181856
local.identifier.catalogId02464346
local.ingest.leader04850naa a2200000uu 4500
local.jointTitleIN VITRO CHARACTERIZATION OF CUTANEOUS IMMUNOTOXICITY OF IMMORTALIZED HUMAN KERATINOCYTES HACAT EXPOSED TO REACTIVE AND DISPERSE TEXTILE DYES
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublication19f128e0-8121-4b29-a9db-b75a1a2b1c4b
relation.isAuthorOfPublication3278ba76-fc90-4d93-ab4e-4e6f931bf8ef
relation.isAuthorOfPublication.latestForDiscovery19f128e0-8121-4b29-a9db-b75a1a2b1c4b
Dateien
Sammlungen
Aufsätze