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Veröffentlichung Harmonization of environmental exposure assessment for veterinary pharmaceuticals and biocides(2016) Junker, Thomas; Römbke, Jörg; Hennecke, Dieter; ECT Oekotoxikologie GmbH (Flörsheim am Main); Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie; Deutschland. Umweltbundesamt; Berkner, Silvia; Konradi, SabineThe spread of veterinary medicinal products (VMP) and biocides onto agriculturally used areas repre-sents a very important path of entry into the environment for these product groups. For this reason, current guidance (e.g. „Guideline on determining the fate of veterinary medicinal products in ma-nure“ (EMA/CVMP/ERA/430327/2009) (EMA, 2011) stipulates experimental studies on transfor-mation of VMPs and biocides in manure. Though, the documents only contain basic regulatory re-quirements, whereas an experimental test guideline is still missing, both on EU and OECD level. To allow for a consistent assessment of studies within the registration process, a harmonized interna-tionally accepted and validated test method is needed.A draft test guideline was developed within a previous R&D-Project “Development of test guidance for transformation of veterinary pharmaceuticals and biocides in liquid manure” (Hennecke et al., 2015). The experimental method was examined and revised by an intra-laboratory comparisons as well as an international inter-laboratory comparison (pre-validation ring test).In the present project, an international ring test has been performed and evaluated testing a veteri-nary medicinal product (florfenicol) in pig manure and a biocide (imidacloprid) in cattle manure. Moreover, two international workshops were organized; one at the beginning in connection with pre-ceding project (Hennecke et al., 2015) and one at the end of the project to discuss and evaluate the ring test. Based on the experimental results of the ring test as well as discussions and conclusions of both workshops, a revised draft test guideline was prepared.Veröffentlichung Harmonization of environmental exposure assessment for veterinary pharmaceuticals and bio-cides(2016) Herrchen, Monika; Hennecke, Dieter; Junker, Thomas; Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie; ECT Oekotoxikologie GmbH (Flörsheim am Main); Deutschland. Umweltbundesamt; Berkner, Silvia; Konradi, SabineThe spread of veterinary medicinal products (VMP) and biocides onto agriculturally used areas represents a very important path of entry into the environment for these product groups. For this reason, current guidance (e.g. „Guideline on determining the fate of veterinary medicinal products in manure“ (EMA/CVMP/ERA/430327/2009) (EMA, 2011) stipulates experimental studies on transformation of VMPs and biocides in manure. However, the documents only contain basic regulatory requirements, whereas an experimental test guideline is still missing, both on EU and OECD level. To allow for a consistent assessment of studies within the registration process, a harmonized internationally accepted and validated test method is needed.A draft test guideline was developed within a previous R&D-Project “Development of test guidance for transformation of veterinary pharmaceuticals and biocides in liquid manure” (FKZ 3710 67 422) (Hennecke et al., 2015). The experimental method was examined and revised by an intra-laboratory comparison as well as an international inter-laboratory comparison (pre-validation ring test).In the present project, an international ring test has been performed and evaluated testing a veterinary medicinal product (florfenicol) in pig manure and a biocide (imidacloprid) in cattle manure. Moreover, two international workshops were organized; one at the beginning in connection with proceeding project (FKZ 3710 67 422) and one at the end of the project to discuss and evaluate the ring test. Based on the experimental results of the ring test as well as discussions and conclusions of both workshops, a revised draft test guideline was prepared.Veröffentlichung Development of a test protocol to study the transformation of veterinary pharmaceuticals and biocides in liquid manure(2015) Hennecke, Dieter; Atorf, Cornelia; Bickert, Claudia; Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie; Deutschland. Umweltbundesamt; Berkner, Silvia; Konradi, Sabine; Lehmann, ReneIt was the aim of the project to develop a method to determine the transformation of substances in liquid manure. In a first step, the heterogeneity of manure of different type and origin was tested. Furthermore, a procedure was tested which is capable to take samples homogeneously from a manure storage tank. Obviously, representative sampling is possible in case mixing devices which are routinely applied by the farmers are used prior to sampling. In order to get an overview on the variability of liquid manure of different type and origin (pig-/cattle manure; manure sampled in summer and winter, from different regions and livestock breeding) 30 manures were sampled and characterized. Furthermore, temperature (including a temperature profile) in manure tanks was reported in order to select a realistic test temperature. Six manures were selected to perform transformation studies of two veterinary medicinal products (Salicylic acid, Paracetamol) and a biocide. The experimental methodology which was developed in the project was used in a first inter-laboratory comparison (ring test) with 5 laboratories. Experiences of the participants were presented and discussed on a workshop and based on the results the developed test protocol was adapted.