Auflistung nach Autor:in "Schröter-Kermani, Christa"

Gerade angezeigt 1 - 20 von 27

Ableitung von Umweltqualitätsnormen für Biota und erste Einordnung anhand von Ergebnissen der Umweltprobenbank
(2013) Schröter-Kermani, Christa; Schudoma, Dieter
Biomonitoring of the industrial alkyl pyrrolidone solvents NMP and NEP: specific metabolites in 24-hour urine samples from the German Environmental Specimen Bank (1996/2012)
(2014) Koch, Holger Martin; Ulrich, N.; Schröter-Kermani, Christa; Bader, M.; Käfferlein, H.U.; Brüning, T.; Kolossa-Gehring, Marike
N-Methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) are multi-purpose organic solvents in
industry. Both are developmental and teratogenic toxicants in rodents. NMP is classified as a REACh substanceof very high concern. Because of their toxicological profile and their broad application resulting in a possibleexposure of the general population, NMP and NEP were chosen as target substances for the cooperationproject between the German Federal Ministry for the Environment, Nature Conservation, Building and NuclearSafety (BMUB) and the German Chemical Industry Association (VCI) aiming to establish human biomonitoring(HBM) methods for "newŁ substances of interest. NMP and NEP are metabolized to 5-hydroxy-N-alkyl-2-pyrrolidones (5-HNMP, 5-HNEP) and 2-hydroxy-N-alkylsuccinimides (2-HMSI, 2-HESI). We analyzed thesespecific metabolites in 24-hour urine samples from the German Environmental Specimen Bank. For thispurpose, 20 randomly selected samples collected in 1996 and in 2012, respectively, were analyzed by asensitive and specific GC-MS/MS method with isotope dilution quantification. We detected NMP metabolites in100% and NEP metabolites in 95% of all samples. Despite the considerable differences in the elimination halftimesof the alkyl pyrrolidone metabolites, the correlations between the metabolites were rather strong (NMP:r=0.51; NEP: r=0.67). An exposure determined through one metabolite is thus confirmed by the other129metabolite. Median NMP metabolite levels were comparable between 1996 (5-HNMP 50 ìg/L, 2-HMSI 46 ìg/L)and 2012 (5-HNMP 39 ìg/L, 2-HMSI 41 ìg/L). Surprisingly, urinary levels of NEP metabolites were approx. 10times higher in 1996 (5-HNEP 14 ìg/L, 2-HESI 42 ìg/L) as compared to 2012 (5-HNEP ~1 ìg/L, 2-HESI 5ìg/L). We would have expected a reverse trend for NEP since NEP has only recently been introduced into themarket as a substitute for NMP. The sources of past and present exposures to NMP and NEP warrant furtherinvestigations.
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S. 128
Daily intake and hazard index of parabens based upon 24 h urine samples of the German Environmental Specimen Bank from 1995 to 2012
(2016) Moos, Rebecca K.; Apel, Petra; Schröter-Kermani, Christa; Kolossa-Gehring, Marike; Brüning, Thomas; Koch, Holger M.
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1.1Ţg/kg bw/day for iso-butyl paraben and 47.5Ţg/kg bw/day for methyl paraben. The calculated DIs were compared with acceptable levels of exposure to evaluate the hazard quotients (HQs) that indicate that acceptable exposure is exceeded for values of >1. Approximately 5% of our study population exceeded this threshold for individual paraben exposure. The hazard index (HI) that takes into account the cumulative risk of adverse estrogenic effects was 1.3 at the 95th percentile and 4.4 at maximum intakes, mainly driven by n-propyl paraben exposure. HI values of >1 indicate some level of concern. However, we have to point out that we applied most conservative assumptions in the HQ/HI calculations. Also, major exposure reduction measures were enacted in the European Union after 2012. Quelle: www.nature.com
Die Umweltprobenbank
(2016) Conrad, André; Kolossa-Gehring, Marike; Körner, Andrea; Schröter-Kermani, Christa; Koschorreck, Jan; Mohaupt, Volker; Fliedner, Annette; Rüther, Maria; Rüdel, Heinz; Deutschland. Umweltbundesamt
Die Umweltprobenbank des Bundes (UPB) ist ein Archiv. Proben des Menschen und der Umwelt lagern dort bei sehr tiefen Temperaturen. Mit den regelmäßig gesammelten Proben können wir den Zustand unserer Umwelt dokumentieren und beobachten, wie sich die Belastung durch natürliche und anthropogene (Schad)Stoffe mit der Zeit verändert. Die Proben der UPB werden so gewonnen, transportiert, aufgearbeitet und gelagert, dass ihre biologische und chemische Information auch über lange Zeiträume konstant bleibt. Auf diese Weise machen es Umweltprobenbankenmöglich, dass wir aktuelle Proben mit Archivmaterial vergleichen können, das vor Jahrzehnten gesammelt und eingelagert wurde.Quelle: https://www.umweltbundesamt.de
Die Umweltprobenbank des Bundes
(2016) Schröter-Kermani, Christa; Gies, Andreas; Kolossa-Gehring, Marike
Die Umweltprobenbank des Bundes (UPB) hat das Ziel, biologische Proben aus der Umwelt und vom Menschen über lange Zeit veränderungsfrei zu lagern, um sie für zukünftige Forschung zu archivieren. Sie bietet die einzigartige Möglichkeit, die Belastung der Umwelt und des Menschen über einen langen Zeitraum zu verfolgen. Die UPB wurde parallel zur Erarbeitung des ersten deutschen Chemikaliengesetzes in den 1970er-Jahren konzipiert. Im Jahr 1979 begann sie ihren Probebetrieb. Nachdem 1982 das Chemikaliengesetz in Kraft trat, begann die UPB 1985 ihren dauerhaften Regelbetrieb. Mit der europäischen Chemikalienverordnung REACH wurde 2007 die Verantwortung für die Sicherheit der vermarkteten Chemikalien und die Aufgabe der Risikobewertung maßgeblich der Industrie übertragen. Seitdem ist die UPB noch wichtiger geworden, um die eigenverantwortliche Bewertung der Industrie zu überprüfen, den Erfolg von Minderungsmaßnahmen zu evaluieren und damit letztlich den Schutz von Mensch und Umwelt vor schädlichen Umwelteinflüssen sicherzustellen. Dies geschieht durch regelmäßige Beobachtung der Belastungen und Analyse zeitlicher Trends. Die Ergebnisse der UPB dienen heute der Beratung der politischen Entscheidungsträger über die Notwendigkeit, Maßnahmen zu ergreifen. Informationen zur Belastungsprävention werden für die Allgemeinbevölkerung und den öffentlichen Gesundheitsdienst zur Verfügung gestellt. Die UPB ist somit ein wichtiges Monitoringinstrument des Bundesministeriums für Umwelt, Naturschutz, Bau und Reaktorsicherheit und kooperiert mit namhaften Forschungs- und Universitätsinstituten. Das Umweltbundesamt konzeptioniert und steuert die Arbeit der UPB, leitet die wissenschaftliche Auswertung der Daten und bereitet diese für die Umweltpolitik und die Öffentlichkeit auf.
Quelle: http://link.springer.com/
Dioxine und dioxinähnliche PCB in Umwelt und Nahrungsketten
(2013) Behnke, Anja; Blondzik, Katrin; Böhnhardt, Anna; Bussian, Bernd M.; Dauert, Ute; Gärtner, Philipp; Giese, Evelyn; Juhrich, Kristina; Knetsch, Gerlinde; Konietzka, Rainer; Minkos, Andrea; Plickert, Sebastian; Rappolder, Marianne; Schmidt, Simone; Schröter-Kermani, Christa; Utermann, Jens; Deutschland. Umweltbundesamt
Dioxine und dioxinähnliche PCB in Umwelt und Nahrungsketten
(2017) Behnke, Anja; Blondzik, Katrin; Böhnhardt, Anna; Bussian, Bernd M.; Dauert, Ute; Fettig, Ina; Gärtner, Philipp; Giese, Evelyn; Juhrich, Kristina; Knetsch, Gerlinde; Konietzka, Rainer; Koschorreck, Jan; Markard, Christiane; Minkos, Andrea; Moriske, Heinz-Jörn; Plickert, Sebastian; Rappolder, Marianne; Schmidt, Simone; Schröter-Kermani, Christa; Utermann, Jens; Deutschland. Umweltbundesamt
Dioxine und dioxinähnliche polychlorierte Biphenyle (dl-PCB) gehören zu den gefährlichsten Umweltgiften. Obwohl die Dioxin-Emissionen seit 1990 in Deutschland und Europa deutlich verringert und der Einsatz von PCB 1989 verboten wurde, kommen Dioxine und PCB aufgrund ihrer Langlebigkeit noch immer in der Luft, im Boden oder in Gewässersedimenten vor und gelangen so in die Nahrungskette von Tier und Mensch. Um das zu vermeiden, ist es notwendig, alle Quellen aufzuspüren und die Belastungen der Umwelt weiter zu minimieren. Das aktualisierte Hintergrundpapier des Umweltbundesamtes informiert ausführlich über die Zusammenhänge zwischen der Belastung von Umwelt und tierischen Nahrungsmitteln durch Dioxine und dl-PCB - von der Entstehung über den Transfer in die Nahrungsketten bis zu den Wirkungen auf den Menschen. Quelle: https://www.umweltbundesamt.de
Dioxine und dioxinähnliche PCB in Umwelt und Nahrungsketten
(2013) Behnke, Anja; Blondzik, Katrin; Böhnhardt, Anna; Bussian, Bernd M.; Dauert, Ute; Gärtner, Philipp; Giese, Evelyn; Juhrich, Kristina; Knetsch, Gerlinde; Konietzka, Rainer; Minkos, Andrea; Plickert, Sebastian; Rappolder, Marianne; Schmidt, Simone; Schröter-Kermani, Christa; Utermann, Jens; Deutschland. Umweltbundesamt
DPHP metabolites in urine samples of the German Environmental Specimen Bank from 1999 to 2012
(2014) Schütze, Andre; Gries, Wolfgang; Kolossa-Gehring, Marike; Apel, Petra; Schröter-Kermani, Christa; Brühning, Thomas; Leng, Gabriele; Koch, Holger Martin
The aim of this study was to investigate a possible time trend and status quo of
dipropylheptylphthalate (DPHP) exposure. DPHP is used as a substitute of other high molecular weightphthalates in high temperature applications (e.g cable wires, roofing membranes, etc.). DPHP was selected inthe cooperation project between the German Federal Ministry for Environment (BMU) and the German ChemicalIndustry Association (VCI) due to its listing as High Production Volume (HPV) chemical in the European Union.The BMU-VCI project establishes new human biomonitoring methods and biomarkers for fifty emergingsubstances. 300 urine samples (24-hour voids) from the German Environmental Specimen Bank were analyzedfor three specific, secondary oxidized DPHP metabolites (with hydroxyl, oxo and carboxy modifications of thealkyl side chain). Urine samples were collected in the years 1999, 2003, 2006, 2009 and 2012, 60 samples peryear, from 30 male and 30 female volunteers (age: 21-29 years). The samples were analyzed by liquid/liquidextraction followed by GC-HRMS, which enabled us to distinguish between DPHP and Di-iso-decyl phthalate(DiDP) metabolites. The limit of quantification was between 0.15 ìg/l and 0.3 ìg/l, depending on the metabolite.All samples were blinded before analysis. DPHP metabolites were not detected in the years 1999-2006.Thereafter, detection rates increased from 3.3% in 2009 to 21.7% in 2012. As expected, mono-oxo-propylheptylphthalate (oxo-MPHP) was the most abundant metabolite, with concentrations between Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.128
Ergebnisse der EU Humanbiomonitoring-Projekte COPHES und DEMOCOPHES in Deutschland
(2013) Fiddicke,Ulrike; Kolossa-Gehring, Marike; Seiwert, Margarete; Schwedler, Gerda; Ißleb, S.; Conrad, André; Schröter-Kermani, Christa; Biot, P.; Casteleyn, L.; Joas, R.
Experiences from the German Environmental Survey (GerES) and the German Environmental Specimen Bank (ESB)
(2014) Conrad, André; Schulz, Christine; Schröter-Kermani, Christa; Rüther, Maria; Seiwert, Margarete; Lermen, D.; Wintermeyer, Dirk; Kolossa-Gehring, Marike
Introduction & methods: The German health-related environmental monitoring program investigates
human exposures to environmental stressors and consists of the German Environmental Survey (GerES) andthe Environmental Specimen Bank (ESB). In addition to human biomonitoring (HBM) and indoor monitoring fordifferent segments of the general population, standardized interviews performed in GerES yield reference dataon exposure influencing factors. The ESB obtains and cryo-preserves i. a. HBM samples, physiologicalparameters, and self-administered questionnaire data on exposure-relevant behaviors from adults (20-29 yrs.)on a yearly basis focusing on temporal changes. Results: Children in GerES IV spent 15 h 31 min at home (4:46in other indoor environments, 3:43 outdoors) differing by socio-economic status. Exposure models indicate thetime spent at home being less important for inhalative exposures than indoor pollutant levels. The ESBdocuments how the decreasing fraction of participants with dental amalgam (1997: 83 % vs. 2013:10 %) isassociated with decreasing urinary mercury (1997: 0.6 ìg/L vs. 2013: 0.07 ìg/L). ESB data on decreasing 24 hurine volumes (1986: 1.3 L vs. 2013: 2.0 L) allows for adjusting time trends in internal exposure. Conclusions &Outlook: GerES and ESB demonstrate how exposure factors can be generated within regularly conducted177population studies. As for all participants also pollutant monitoring data are available, individual associationsbetween exposure factors and internal exposures to various contaminants can be investigated. These analysescan also account for socio-demographic differences and time trends in exposure relevant behaviors. The furtherdevelopment of both studies includes online-questionnaires and interviews on potential sources of emerging pollutants. Acknowledgements: We thank the German Ministries for the Environment (BMUB) and Research(BMBF) for funding and the Robert Koch-Institute for good cooperation in GerES.
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.176-177
Glyphosate in German adults - Time trend (2001 to 2015) of human exposure to a widely used herbicide
(2017) Conrad, André; Schröter-Kermani, Christa; Hoppe, Hans-Wolfgang; Kolossa-Gehring, Marike; Pieper, Silvia; Rüther, Maria
Integrating Experience from Cross-sectional Studies and Bio banking in the Development of a Large Scale Birth Cohort
(2013) Kolossa-Gehring, Marike; Conrad, André; Apel, Petra; Fiddicke, Ulrike; Schulz, Christine; Schröter-Kermani, Christa; Seiwert, Margarete
Background and aim: Harmonization of questionnaires to assess environmental exposures is among the objectives of theEnvironment and Child Health International Birth Cohort Group. Questionnaires are more difficult to harmonize than biologicalor environmental sampling because of language and cultural specificities. They are however important tools to assess the routeof expositions. Methods: The first step of the work has been to gather questionnaires from all the birth cohorts on specificchosen exposures and to translate them into English. The second step will be to produce descriptive statistics from data of pilotor ongoing phases of the different cohorts. The third step will be to analyze the questions in relation to biological orenvironmental measurements in the different countries (not yet available) and to produce recommendations to select the morepertinent questions. Results: The first step highlighted the great diversity of questions provided by the experts from eachcountry and the absence of validated reference questionnaires at the national as well as at the international level. Descriptivestatistics for the assessment of domestic use of pesticides in the US, Japanese, and Chinese birth cohorts will be shown anddiscussed as an example. Conclusion: Environmental epidemiology is a recent field compared to other domains and there is aneed for standardization of questionnaires. The work of the Environment and Child Health International Birth Cohort Group is astep forward to allow selection of questions pertinent for a given exposure. Test retest reliability and back translation into
different languages will also be an important issue to tackle.Quelle: Conference on Environment and Health Basel 2013
Integrating Exposure Modeling with Human Biomonitoring: Experiences from Health-related Environmental Monitoring in Germany
(2015) Conrad, André; Plaß, Dietrich; Tobollik, Myriam; Schulz, Christine; Seiwert, Margarete; Schröter-Kermani, Christa; Rüther, Maria; Schwedler, Gerda; Rucic, Enrico; Wintermeyer, Dirk; Kolossa-Gehring, Marike
Introduction:
The German health-related environmental monitoring program - consisting of the German Environmental Survey (GerES) and the Environmental Specimen Bank (ESB) - is also a key source for the German Exposure factors database (RefXP). Current GerES and ESB results and updated exposure factors in RefXP are combined for the analysis of environmental health topics. Methods GerES is a cross-sectional population study carried out repeatedly since 1985. GerES comprises human biomonitoring (HBM), indoor monitoring and interviews. On a yearly basis, the ESB collects human samples which are cryo-archived and analyzed for various pollutants. All 20-29 years old ESB participants report on their behaviors and anthropometrics. RefXP includes approx. 1,000 entries on exposure factors for the German population, e.g. body-weight, food consumption, and soil/dust ingestion.
Results:
GerES and RefXP data were used to estimate German childrens inhalative exposure to indoor air pollutants. For alpha-pinene the median estimate is 2.7, for xylene 1.4 ìg/(kg d). GerES interviews revealed substantial seasonal differences in ventilation behavior, indicating the need for separate exposure models for summer and winter. ESB data documents time trends in human exposures and in exposure influencing factors: Urinary mercury decreased from 0.6 in 1997 to 0.07 ìg/L in 2013. This can partly be explained by a decreasing fraction of participants with dental amalgam (1997: 83% vs. 2013: 10%).
Conclusions:
Combining data from GerES, ESB, and RefXP yields a more complete view on environmental exposures in the German population: Integrating HBM and exposure modelling provides comprehensive data on exposures, relevant exposure pathways, and information on the potential effect of policy measures aiming for improving environmental health. Acknowledgements GerES, ESB and RefXP are funded by the Federal Environment Ministry (BMUB). Further information: www.uba.de/geres, www.umweltprobenbank.de, www.uba.de/refxp
In: The International Societyof Exposure Science: 25th Annual Meeting: Exposures in an Evolving Environment; October 18 - 22, 2015 - Henderson, Nevada, S.151
Measuring environmental contaminants in humans
(2013) Kolossa-Gehring, Marike; Seiwert, Margarete; Schwedler, Gerda; Fiddicke, Ulrike; Conrad, André; Schröter-Kermani, Christa; Schulz, Christine; Biot, Pierre; Aerts, Dominique; Casteleyn, Ludwine; Joas, Anke; Joas, Reinhard
New human biomonitoring methods for chemicals of interest
(2014) Fiddicke,Ulrike; Kolossa-Gehring, Marike; Apel, Petra; Schröter-Kermani, Christa; Bader, Michael; Leng, Gabriele; Koch, Holger M.
Introduction The German initiative to develop new human biomonitoring (HBM) methods forsubstances of interest is a cooperation of the Federal Ministry for the Environment, Nature Conservation,Building and Nuclear Safety (BMUB) and the German Chemical Industry Association (VCI) which started in2010. Emphasis is placed on substances either with potential health relevance or for which an exposure of the
general population can be assumed. Methods After identification of relevant chemicals by an expert panel HBMmethods are developed and first applied to about 40 non occupationally exposed persons. The analyticalmethods are cross-validated by the working group ´Analyses in biological Materials of the German ResearchFoundation (DFG) and published together with pilot-test results in international, peer-reviewed journals. ResultsNew HBM methods for methylenediphenyl diisocyanate (MDI ), used in polyurethane and adhesives, thevulcanization accelerator 2-mercaptobenzothiazole (2-MBT), the plasticizer alternatives Hexamoll® DINCH anddi-2-propylheptyl phthalate (DPHP), the alkylphenols 4-tert-octylphenol and 4-nonylphenol and the technicalsolvents N-methyl- and N-ethyl-2-pyrrolidone (NMP/NEP) have already been developed and applied. For someof these chemicals a considerable background exposure seems to be unlikely (e.g. MDI), for other substances(e.g. NMP/NEP) a ubiquitous background was detected. For DINCH and DPHP, trends of increasing exposurewere observed in urine samples from the German Environmental Specimen Bank, mirroring the marketintroduction of the substances. The relevance of the findings needs to be assessed by toxicologically derivedHuman Biomonitoring Values (Biomonitoring Equivalents) and by population representative studies.Consequently, we plan to include these substances in the 5th German Environmental Survey. The results willcontribute to a realistic exposure and risk assessment for these "newŁ chemicals in German children.
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstract Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.159
Screening-Studie zur Glyphosat-Exposition der Menschen in Deutschland
(2015) Schröter-Kermani, Christa; Conrad, André; Hoppe, Hans-Wolfgang; Kolossa-Gehring, Marike
The exposure of German children and young adults to chemicals of concern
(2013) Apel, Petra; Conrad, André; Fiddicke, Ulrike; Schröter-Kermani, Christa; Schulz, Christine; Seiwert, Margarete
The German Environmental Specimen Bank (ESB): Monitoring Phased-out and Emerging Pesticides
(2014) Schröter-Kermani, Christa; Conrad, André; Hoppe, Hans-Wolfgang; Kolossa-Gehring, Marike
Introduction and methods: The ESB regularly collects human samples which are analyzed for various
substances before being cryo-archived. Every year i. a. 24 h-urine and blood samples from 480 young adults(20-29 years of age) from four German cities are acquired. To document time trends in human exposure topesticides samples have been regularly analyzed for Hexachlorobenzene (HCB) and Pentachlorophenol (PCP)since the 1980s. As initial retrospective analysis 40 urine samples acquired in 1996 and 2012 have beenanalyzed for N-(phosphonomethyl)glycine (Glyphosate). Results: ESB data reveal a major decrease in averageinternal exposures to HCB (1985: 2.7 ìg/L vs. 2010: 0.09 ìg/L blood plasma) and PCP (1985: 26.7 ìg/L vs.2010: 0.54 ìg/L blood plasma). Until the 1990s, HCB tends to be higher in females. No substantial gender difference for this period was observed for PCP. The internal Glyphosate exposure increased significantlybetween 1996 and 2012. The fraction of quantifiable levels increased from 40% to 70%. On average theconcentration increased from below LOD (0.15 ìg/L) to 0.21 ìg/L urine. The highest Glyphosate valuemeasured in 2012 resulted in 0.65 ìg/L urine. Against expectation the concentration of Glyphosates mainmetabolite Aminomethylphosphonic acid (AMPA) did not increase in time. Also no significant correlation wasobserved between Glyphosate and AMPA levels. Conclusions and Outlook: ESB data document the effect ofbanning PCP and HCB in Germany in the 1980s. Concerning Glyphosate ESB measurements are in line withthe increasing application of this pesticide resulting in an increasing exposure of the population. Levelsmeasured in 2012 are well below toxicologically relevant concentrations. However, due to the ongoingdiscussion on health effects of Glyphosate further monitoring is warranted. Acknowledgements: The ESB isfunded by the Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB).
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S. 29
The German Environmental Specimen Bank - Human exposure to emerging chemicals and their regulation
(2014) Kolossa-Gehring, Marike; Schröter-Kermani, Christa; Rüther, Maria; Conrad, André; Apel, Petra
Europeans are still substantially exposed tochemicals. Toxicological and epidemiological studies
have revealed several associations between exposureand health effects for numerous substances. InGermany exposure to various chemicals is well documentedby the German Environmental Survey (GerES)and the Environmental Specimen Bank CESB). Many relevantsources of exposure and chemicals of concernhave changed over time: While in the past ambient airand drinking water were particularly important, today'smain sources are nutrition, indoor air, cosmetics, andconsumer products. After identification of substancesof toxicological relevance and to which the generalpopulation might considerably be exposed new humanbiomonitoring (HBM) methods for i. a. the sensitizingagent methylenediphenyldiisocyanate (MDI), the two
plasticisers Hexamoll® DI NCH®,Di-2-propylheptylphthalate CDPHP)- both substitutes for Di-2-ethylhexylphthalate (DEHP)- and parabenes have beendeveloped and-if appropriate- applied to ESB samples.While MDI and DPHP seem not to be related with ameasurable exposure of occupationally non-exposedpersons, DINCH levels increase constantly since marketingof this new substance.The relevance of thesefindings is to be assessed by derivation of toxicological
Human-Biomonitoring-Values as well as by HBMstudies in the population-representative GerES V. ln vestigationof chemicals relevant today by HBM helpsto prioritize futher toxicological investigations andprovides guidance for consumer decisions and policy.However, a continuous monitoring also of well knownsubstances is essential for assessing impacts of chemicals
on children. GerES and ESB are funded by theFederal Ministries for the Environment as well as Educationand Research.
Quelle: Programme Book : ESBB Annual Meeting, October 21-24, 2014 / ESBB. Leipzig, 2014, S. 32-33