Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints
Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints
Autor:innen
Herausgeber
Quelle
Schlagwörter
Genexpression, Biomarker, ecotoxicology testing, hormonally active agent, identification of pollutants, gene expression, fish sexual development test
Finanzierungskennzeichen
standardisiertes Finanzierungskennzeichen
Verbundene Publikation
Zitation
MUTH-KÖHNE, Elke, Martina FENSKE und Matthias TEIGELER, 2016. Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints [online]. Texte, 41/2016. Verfügbar unter: https://openumwelt.de/handle/123456789/7545
Zusammenfassung deutsch
For the evaluation of effects of hormone-active substances to fish, several test guidelines have been validated by the OECD which are included in the Conceptual Framework for Testing and Assessment of Endocrine Disruptors (OECD, 2010). In these tests, the assessment of physiological parameters is limited to the established biomarkers like vitellogenin or 11-keto testosterone in blood plasma or liver tissue. A promising approach
to refine existing testing strategies is the integration of molecular endpoints, which rapidly respond to exposure. Furthermore, these endpoints can be indicative of potential adverse effects at the organismal level by providing information, which connect to the initiating effect of a substance. This is in line with the concept of Adverse Outcome Pathways (AOP), which evolved from the "toxicity pathwayŁ approach as a mechanistic evaluation tool for the risk assessment.
Quelle: https://www.umweltbundesamt.de/
to refine existing testing strategies is the integration of molecular endpoints, which rapidly respond to exposure. Furthermore, these endpoints can be indicative of potential adverse effects at the organismal level by providing information, which connect to the initiating effect of a substance. This is in line with the concept of Adverse Outcome Pathways (AOP), which evolved from the "toxicity pathwayŁ approach as a mechanistic evaluation tool for the risk assessment.
Quelle: https://www.umweltbundesamt.de/
Zusammenfassung englisch
For the evaluation of effects of hormone-active substances to fish, several test guidelines have been validated by the OECD which are included in the Conceptual Framework for Testing and Assessment of Endocrine Disruptors (OECD, 2010). In these tests, the assessment of physiological parameters is limited to the established biomarkers like vitellogenin or 11-keto testosterone in blood plasma or liver tissue. A promising approachto refine existing testing strategies is the integration of molecular endpoints, which rapidly respond to exposure. Furthermore, these endpoints can be indicative of potential adverse effects at the organismal level by providing information, which connect to the initiating effect of a substance. This is in line with the concept of Adverse Outcome Pathways (AOP), which evolved from the “toxicity pathway” approach as a mechanistic evaluation tool for the risk assessment.