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Veröffentlichung Human biomonitoring and biobanking for identifying time trends of human exposure(2013)For the last 40 years human biomonitoring is an essential tool for protecting health and monitoring
environmental chemicals in Germany. Since 1985 four German Environmental Surveys (GerES)
have been conducted. These surveys are cross sectional representative population studies aiming
to determine the contamination with environmental pollutants of the general population living in
Germany. Up to now more than 14,000 subjects were questioned with a standardized
questionnaire and tested for the concentrations of environmental chemicals in blood and urine in
GerES. Additionally contaminants in indoor air, house dust, and tap water were analyzed to identify
routes of exposure and to interpret human biomonitoring data on concentrations of xenobiotics.
Additionally the German Environmental Specimen Bank (ESB) archives human samples of blood,
blood plasma, and urine. Since 1985 annually 400 to 500 students from four major university cities
donate specimen that stored at ultra low temperature. The resulting archive allows for retrospective
analysis. The main purpose of the archive is reviewing earlier data with new analytical procedures
as well as determining the extent to which older samples are contaminated with pollutants that
have only just been discovered.
Both instruments show that in Germany the concentration long known persistent chemicals like
heavy metals and POPs have declined over the last decade. Without doubt this is the effect of a
stringent and successful environmental legislation on chemicals. On the other hand new
substances have emerged like polyfluorinated compounds, phthalates and bisphenol A. Analysis of
phthalate metabolites in urine samples show that some of the traditional phthalates like DEHP have
exhibited declining trends while others like DINP become more and more prominent as substitutes
of banned or restricted softeners. A combined risk analysis shows that a considerable part of the
German children are still at risk of facing negative health outcomes due to phthalate exposure.
Data from the German Environmental Survey and the Environmental Specimen Bank are powerful
tools to control exposure, identify time trends that may be problematic for human health. Risk
assessment conducted on the basis of measured exposure data can complement assessments incourse of chemicals legislation that are mainly based on model assumption.
Quelle: Human biomonitoring and biobanking for identifying time trends of human exposure [Elektronische Ressource] / Andreas Gies ... - Boston, 2013. - 27 Vortragsfolien : Ill., graph. Darst.