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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2014
The ex-vivo intestinal absorption rate of uranium is a two-phase function of supply
The ex-vivo intestinal absorption rate of uranium is a two-phase function of supply
Autor:innen
Herausgeber
Quelle
Regulatory Toxicology and Pharmacology
69 (2014), H. 2, Seite 256-262
69 (2014), H. 2, Seite 256-262
Schlagwörter
Uran, Dünndarm, Resorption
Finanzierungskennzeichen
standardisiertes Finanzierungskennzeichen
Verbundene Publikation
Zitation
KONIETZKA, Rainer, 2014. The ex-vivo intestinal absorption rate of uranium is a two-phase function of supply. Regulatory Toxicology and Pharmacology [online]. 2014. Bd. 69 (2014), H. 2, Seite 256-262. DOI 10.60810/openumwelt-2034. Verfügbar unter: https://openumwelt.de/handle/123456789/8560
Zusammenfassung englisch
The concentration-dependent absorption behaviour of uranium was investigated with surviving intestinal segments of rat jejunums, using an ex-vivo model. The results showed a monotonic slightly nonlinear increase in absorption as uranium concentrations increased. This trend was observed over the entire concentration range tested. In the lower concentration range a slower linear ascent was observed while a steeper linear ascent was found for the higher concentration range. Statistical fit was only slightly poorer for an exponential function in the range of lower values and a logarithmic function in the range of higher values. The proportion of uranium absorbed expressed as percent of uranium concentrations in the perfusion solutions followed a monotonically increasing trend from 20 to around 200 ìg/l uranium in the perfusion solutions, which thereafter appears to reach a plateau, as further increase towards concentrations around 400 ìg/l is not substantial. The uranium concentration administered had no effect on the vitality and consequently the functionality of the intestinal segments, measured in terms of active glucose transport. The results imply that uranium concentrations of more than 20 ìg/l in drinking water, for example, could lead to elevated absorption rates and thus to higher internal exposures to consider when setting of Guideline values in this concentration range.Quelle: http://www.sciencedirect.com