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Publikationstyp
Conference proceedings
Monographie
Monographie
Erscheinungsjahr
2021
DOI
Breast-feeding duration and maternal age contributing to the body burden of perfluorinated alkylated substances (PFAS)
Breast-feeding duration and maternal age contributing to the body burden of perfluorinated alkylated substances (PFAS)
Results of the German Environmental Survey for Children and Adolescents 2014-2017 (GerES V)
Autor:innen
Herausgeber
Quelle
31th Annual Meeting of the International Society of Exposure Science (31., 2021, online)
Schlagwörter
Forschungskennzahl (FKZ)
Verbundene Publikation
Zitation
Breast-feeding duration and maternal age contributing to the body burden of perfluorinated alkylated substances (PFAS), 2021. [online]. Boston. Verfügbar unter: https://openumwelt.de/handle/123456789/3173
Zusammenfassung englisch
Perfluoroalkyl substances (PFAS) such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are ubiquitously found in humans across all age groups. The German Environmental Survey for Children and Adolescents carried out from 2014 to 2017 (GerES V) revealed detectable blood plasma levels of PFAS in all participants. Two third of the participants had blood plasma levels above the limit of quantification (0.25-0.50 (micro)g/L) simultaneously for PFOA, PFOS, and perfluorohexane-1-sulphonic acid (PFHxS). The health-based guidance values I (HBM-I) derived by the German Human Biomonitoring Commission of 2 (micro)g/L for PFOA and 5 (micro)g/L for PFOS were exceeded by 21% and 7% of the participants. For these participants adverse health effects cannot be ruled out with sufficient certainty. Another 0.2% even exceeded the HBM-II value for PFOS of 20 (micro)g/L for the general population and 10 (micro)g/L for women of child-bearing age, respectively, which is regarded as intervention or action level. PFAS are found to substantial extent even in the youngest children born after the ban of PFOS in 2006, underlining the problematic and long-lasting effects of persistent chemicals. PFAS contamination is evident globally in various environmental compartments, food as well as breast milk. The aim of this study is to quantify the effect of relevant sources of PFAS exposure on children and adolescents in Germany, including various sociodemographic characteristics, living environment, dietary preferences, breast-feeding history, and tap water contamination. Breast-feeding duration and maternal age are significantly correlated with log-transformed plasma concentrations of PFOA, PFOS, and PFHxS (pearson correlation coefficients 0.12-0.24, p < 0.001) - i.e. higher maternal age and longer breast-feeding duration are associated with higher PFAS levels in the offspring. Multivariate analyses are used to quantify the contribution of exposure sources to internal PFAS exposure. The results suggest that, while breast-feeding is generally encouraged due to its various positive health effects, recommendations regarding breast-feeding duration should consider the PFAS burden of mothers especially when they have their first child only at relatively high age. © The Authors 2021