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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2023
Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries
Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries
Autor:innen
Herausgeber
Quelle
Infectious diseases of poverty
12 (2023)
12 (2023)
Schlagwörter
Finanzierungskennzeichen
standardisiertes Finanzierungskennzeichen
Verbundene Publikation
Zitation
OLARU, Ioana D., Birgit WALTHER und Frieder SCHAUMBURG, 2023. Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries. Infectious diseases of poverty [online]. 2023. Bd. 12 (2023). DOI 10.60810/openumwelt-206. Verfügbar unter: https://openumwelt.de/handle/123456789/1624
Zusammenfassung englisch
Background Antimicrobial resistance is an increasing challenge in low and middle-income countries as it is widespread in these countries and is linked to an increased mortality. Apart from human and environmental factors, animal-related drivers of antimicrobial resistance in low- and middle-income countries have special features that differ from high-income countries. The aim of this narrative review is to address the zoonotic sources and the spread of antimicrobial resistance from the perspective of low- and middle-income countries. Main body Contamination with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli is highest in poultry (Africa: 8.9-60%, Asia: 53-93%) and there is a risk to import ESBL-producing E. coli through poultry meat in Africa. In aquacultures, the proportion of ESBL-producers among E. coli can be high (27%) but the overall low quality of published studies limit the general conclusion on the impact of aquacultures on human health. ESBL-producing E. coli colonization of wildlife is 1-9% in bats or 2.5-63% birds. Since most of them are migratory animals, they can disperse antimicrobial resistant bacteria over large distances. So-called 'filth flies' are a relevant vector not only of enteric pathogens but also of antimicrobial resistant bacteria in settings where sanitary systems are poor. In Africa, up to 72.5% of 'filth flies' are colonized with ESBL-producing E. coli, mostly conferred by CTX-M (24.4-100%). While methicillin-resistant Staphylococcus aureus plays a minor role in livestock in Africa, it is frequently found in South America in poultry (27%) or pork (37.5-56.5%) but less common in Asia (poultry: 3%, pork: 1-16%). Conclusions Interventions to contain the spread of AMR should be tailored to the needs of low- and middle-income countries. These comprise capacity building of diagnostic facilities, surveillance, infection prevention and control in small-scale farming. © The Author(s) 2023.