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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2023
Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?
Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?
Autor:innen
Herausgeber
Quelle
Environmental Sciences Europe
35 (2023)
35 (2023)
Schlagwörter
Persistenz
Zitation
BERKNER, Silvia und Ute BRANDT, 2023. Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes? Environmental Sciences Europe [online]. 2023. Bd. 35 (2023). DOI 10.60810/openumwelt-2180. Verfügbar unter: https://openumwelt.de/handle/123456789/1679
Zusammenfassung englisch
Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a decision criterion in a safe and sustainable by design framework. Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308). The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases. © The Author(s) 2023