Vorschaubild nicht verfügbar
Publikationstyp
Conference proceedings
Monographie
Monographie
Erscheinungsjahr
2015
DOI
Sharing experiences from human biomonitoring studies and programs in Germany and Europe
Sharing experiences from human biomonitoring studies and programs in Germany and Europe
Autor:innen
Herausgeber
Quelle
25th annual meeting of the International Society of Exposure Science (ISES)
Schlagwörter
Biomonitoring, Epidemiologie
Zitation
Sharing experiences from human biomonitoring studies and programs in Germany and Europe, 2015. [online]. Verfügbar unter: https://openumwelt.de/handle/123456789/7731
Zusammenfassung englisch
The Health Research Framework Program of the German Federal Government identifies birth cohorts as the instrument of choice to elucidate relationships between exposure to environmental chemicals, well-being of infants and children, and health in later life. But even large scale birth cohorts can for practical reasons - sample collection, burden of participants, and costs - not cover all issues of concern. Therefore, integrating experiences from other national and international studies is necessary for setting priorities in the study design, e.g. selection of chemicals to be analyzed. Lessons learned from German and European HBM studies and programs may support this process: 1) Focusing on health relevance and potential exposure of the general population, the scientific agencies in charge of chemical safety in Germany have identified emerging chemicals and assigned high priority to them for being analyzed in population studies. 2) Observed links between chemicals (e.g. fragrances) and health effects in cross-sectional studies further predestine compounds for evaluation in cohort studies. 3) Availability of assessment values is also important when choosing biomarkers: UBAs Human Biomonitoring Commission has derived 6 new toxicologically based HBM values to assess internal exposures. First HBM data on the solvents N-ethyl-2-pyrrolidone and N-methyl-pyrrolidone and the new plasticizer Hexamoll® DINCH and di-2-propylheptyl phthalate (DPHP) show that exposures are well below the specific HBM-I-values. 4) Options for combining data from several international studies may be another reason for decisions on study design. For joint data assessment, transfer of (individual) data and exchange of samples, ethical and data protection standards have to be considered. Experiences from the German Environmental Survey (GerES), the German Environmental Specimen Bank (ESB) and the European HBM project COPHES help solving these issues also in birth cohorts.Quelle: 25th annual meeting of the International Society of Exposure Science (ISES). 18-22 October 2015. Henderson-Nevada USA. URL: http://www.ises2015.org/. We-S-B1-02.S. 179.