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Publikationstyp
Conference proceedings
Konferenzposter
Monographie
Konferenzposter
Monographie
Erscheinungsjahr
2018
DOI
German Environmental Specimen Bank: Characteristics of 24-H urine samples and their relevance for human biomonitoring
German Environmental Specimen Bank: Characteristics of 24-H urine samples and their relevance for human biomonitoring
experience from 20 years of trend research
Autor:innen
Herausgeber
Quelle
Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (2018 : Ottawa)
Schlagwörter
Finanzierungskennzeichen
standardisiertes Finanzierungskennzeichen
Verbundene Publikation
Zitation
German Environmental Specimen Bank: Characteristics of 24-H urine samples and their relevance for human biomonitoring, 2018. [online]. Ottawa. Verfügbar unter: https://openumwelt.de/handle/123456789/5801
Zusammenfassung englisch
For documenting trends in human exposure, the German Environmental Specimen Bank (ESB) has been routinely collecting and archiving 24 h-urine samples from young adults at four sampling sites in Germany. In addition to pollutant concentrations, urinary creatinine (UC), specific gravity (SG), conductivity (CON) and total urine volume (UVtot) have been routinely recorded. It is known that the above-mentioned characteristics of 24 h- urine samples vary between individuals and over time and might affect data interpretation. To identify relevant differences and trends in these parameters, we analysed ESB data from 1997-2016 from 8,916 participants also with regard to the impact of sex, sampling site. Sampling sites do not substantially affect UVtot, UC, SG and CON. A significant increasing trend was revealed for UVtot. This increase is associated with UC, SG, and CON decreasing over time. Effects of normalization against these urine parameters were demonstrated for urinary Ca2+ concentrations: From 1996-2016, Ca2+ showed a significant decreasing trend over time. A normalization against UVtot, UC, or CON eliminated this trend. The known sex specific excretion for Ca2+ is confirmed in this study. A normalization against UC, SG, or CON alleviated differences between sexes whereas a normalization against UVtot did not. To avoid misinterpretations in trend analysis and of sex specific excretion, the collection of 24-h urine samples and the calculation of the total daily excretion is recommended. Also if sampling is limited to spot or morning urine samples, the record of multiple urinary parameters should be considered for supporting data standardization. The suitability of these characterization may, however, vary by the analyte of interest, the study design, and the kind of urine sample taken. Funding by the German Ministry for the Environment (BMU) is gratefully acknowledged. In: ISES-ISEE 2018 Joint Annual Meeting : Abstract book. Ottawa: International Society of Exposure Science, 2018, S. 1521