Publikation:
How to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU

Kurzanzeige
dc.contributor.authorSantonen, Tiina
dc.contributor.authorMahiout, Selma
dc.contributor.authorApel, Petra
dc.contributor.authorAlvito, Paula
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorGerofke, Antje
dc.contributor.authorLange, Rosa
dc.date.accessioned2024-06-16T12:53:45Z
dc.date.available2024-06-16T12:53:45Z
dc.date.issued2023
dc.description.abstractOne of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations. © 2023 The Author(s)en
dc.format.extent1 Online-Ressource (24 Seiten)
dc.format.extent1,12 MB
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1444
dc.identifier.urihttps://openumwelt.de/handle/123456789/2065
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectRisikoanalyse
dc.subjectChemikalien
dc.subjectUmweltbedingte Krankheitslast [EBD]
dc.titleHow to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2023.114139
local.bibliographicCitation.volume249 (2023)
local.collectionAufsätze
local.contributor.authorId02134975
local.contributor.authorId02191917
local.contributor.authorId02191918
local.contributor.authorId02188720
local.identifier.catalogId02497377
local.ingest.leader06628naa a2200000uu 4500
local.jointTitleHOW TO USE HUMAN BIOMONITORING IN CHEMICAL RISK ASSESSMENT METHODOLOGICAL ASPECTS RECOMMENDATIONS AND LESSONS LEARNED FROM HBM4EU
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
local.staffPublicationtrue
relation.isAuthorOfPublication28f9b1e3-5211-44ba-8d52-c462cd5fe32d
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication278393f9-ea5a-4405-87ce-b9bdb9bfb28c
relation.isAuthorOfPublication.latestForDiscovery28f9b1e3-5211-44ba-8d52-c462cd5fe32d
Dateien
Sammlungen
Aufsätze