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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2023
How to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU
How to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU
Autor:innen
Santonen, Tiina
Mahiout, Selma
Alvito, Paula
Gerofke, Antje
Herausgeber
Quelle
International Journal of Hygiene and Environmental Health
249 (2023)
249 (2023)
Schlagwörter
Human-Biomonitoring, Risikoanalyse, Chemikalien, Umweltbedingte Krankheitslast [EBD]
Zitation
SANTONEN, Tiina, Selma MAHIOUT, Petra APEL, Paula ALVITO, Marike KOLOSSA-GEHRING, Antje GEROFKE und Rosa LANGE, 2023. How to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU. International Journal of Hygiene and Environmental Health [online]. 2023. Bd. 249 (2023). DOI 10.60810/openumwelt-1444. Verfügbar unter: https://openumwelt.de/handle/123456789/2065
Zusammenfassung englisch
One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations. © 2023 The Author(s)