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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2021
New models to predict the acute and chronic toxicities of representative species of the main trophic levels of aquatic environments
New models to predict the acute and chronic toxicities of representative species of the main trophic levels of aquatic environments
Autor:innen
Herausgeber
Quelle
Molecules
26 (2021), Heft 22
26 (2021), Heft 22
Schlagwörter
Fisch
Zitation
TOMA, Cosimo, Jürgen ARNING, Claudia Ileana CAPPELLI und Alberto MANGANARO, 2021. New models to predict the acute and chronic toxicities of representative species of the main trophic levels of aquatic environments. Molecules [online]. 2021. Bd. 26 (2021), Heft 22. DOI 10.60810/openumwelt-1104. Verfügbar unter: https://openumwelt.de/handle/123456789/3056
Zusammenfassung englisch
To assess the impact of chemicals on an aquatic environment, toxicological data for three trophic levels are needed to address the chronic and acute toxicities. The use of non-testing methods, such as predictive computational models, was proposed to avoid or reduce the need for animal models and speed up the process when there are many substances to be tested. We developed predictive models for Raphidocelis subcapitata, Daphnia magna, and fish for acute and chronic toxicities. The random forest machine learning approach gave the best results. The models gave good statistical quality for all endpoints. These models are freely available for use as individual models in the VEGA platform and for prioritization in JANUS software. © 2021 by the authors