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Autor:innen
Herausgeber
Quelle
Schlagwörter
in vitro, Biotest, endocrine active substance, pharmaceutical, hormone
Förderkennzeichen (FKZ)
3720644050
Forschungskennzahl
Verbundene Publikation
Zitation
Further development of test methods for hormonally active pharmaceuticals and other substances. (2024). German Environment Agency. https://doi.org/10.60810/openumwelt-7443
Zusammenfassung englisch
Sensor cell lines have been developed to monitor rapid non-genomic signalling cascades influenced by endocrine-active substances. These in-vitro bioassays were created by genetically modifying G-protein coupled estrogen receptor (GPER1) expressing cells to become artificial fluorescent signalosomes. Both GPER1 agonists and antagonistic compounds were used to characterize the respective sensor cells. The bioassays were then used to screen for potential endocrine-disrupting substances. In addition, these assays have been used to evaluate influent and effluent from advanced treatment units in several wastewater treatment plants.