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Tailored Assessment Strategies for Environmental Protection
Autor:innen
Herausgeber
Quelle
Schlagwörter
endocrine active substance, biological effect, ecotoxicology, environmental risk assessment
Förderkennzeichen (FKZ)
3717674050
Forschungskennzahl
Verbundene Publikation
Zitation
New-Generation Steroid Hormones. (2024). [German Environment Agency]. https://doi.org/10.60810/openumwelt-6129
Zusammenfassung englisch
The project generated ecotoxicological data needed for the development of a tailored testing strategy to assess the environmental risk of pharmaceuticals (progestins and glucocorticoids). For this purpose, chronic fish tests, among others, were carried out in the laboratory according to a new test protocol currently undergoing OECD validation investigating dienogest and dexamethasone as test substances. The studies provided reliable and valid results with effect thresholds in the lower µg/L or ng/L range. This has closed data gaps for the development of new assessment approaches for a targeted risk assessment of specifically acting pharmaceuticals. Additional investigations on directed gene expression and immunosuppressive effect assays would complement the assessment strategy for progestins and glucocorticoids.