Publikation:
Considerations about the relationship of nanomaterial´s physical-chemical properties and aquatic toxicity for the purpose of grouping

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dc.contributor.authorHund-Rinke, Kerstin
dc.contributor.authorNickel, Carmen
dc.contributor.authorKühnel, Dana
dc.contributor.organisationOtherFraunhofer-Institut für Molekularbiologie und Angewandte Oekologie
dc.contributor.organisationOtherInstitut für Energie- und Umwelttechnik (Duisburg)
dc.contributor.organisationOtherHelmholtz-Zentrum für Umweltforschung
dc.contributor.organisationalEditorDeutschland. Umweltbundesamt
dc.contributor.otherVölker, Doris
dc.date.accessioned2024-06-16T15:26:34Z
dc.date.available2024-06-16T15:26:34Z
dc.date.issued2017
dc.date.submittedStudy completed in: March 2017
dc.description.abstractProjektziel war die Entwicklung eines Konzeptes, um Nanomaterialien (NM) hinsichtlich ihrer Ökotoxizitat für Algen, Daphnien, und den Fischembryo zu gruppieren. Dabei wurden fünf Arbeitsschritte durchlaufen: (i) Auswahl von insgesamt 14 NM, die sich auf die Materialtypen Ag, ZnO, TiO2, CeO2, und Cu aufteilten; (ii) umfassende physikalischĄ-chemische Charakterisierung aller Materialien in Wasser und den drei Testmedien; (iii) Entwicklung von Hypothesen zur erwarteten Ökotoxizitat; (iv) ökotoxikologische Testung aller NM in den drei ausgewählten Testsystemen; (v) Erprobung verschiedener Gruppierungsänsatze auf Basis der physikalischĄ-chemischen Parameter (PCParameter), die als relevant für die aquatische Ökotoxizitat identifiziert worden waren. Als relevant wurden Morphologie, Stabilität (Ionenfreisetzung, Kristallstruktur) und die Ökotoxizitat der chemischen Verbindung identifiziert und darauf basierend ein Schema zur Gruppierung vorgeschlagen. Es ist jedoch nicht auszuschließen, dass weitere Parameter zu berücksichtigen sind. Es zeigte sich weiterhin, dass keine sinnvolle Gruppierungshypothese auf einem einzelnen PCĄ-Parameter beruhen kann. Für eine sinnvolle Gruppierung ist ein Set von Parametern notwendig. Um das vorgeschlagene Gruppierungskonzept im Hinblick auf die regulatorische Anwendung zukünftig weiterzuentwickeln sind folgende Aspekte zu berücksichtigen: (i) gezielte Berücksichtigung von Oberflächenmodifikationen, die bewusst bei dem Projekt ausgeschlossen worden waren; (ii) Ersatz des Fischembryotests aufgrund seiner geringen Sensitivität; (iii) Anpassung der Methoden zur Bestimmung der Oberflächenreaktivitat, da keine Übereinstimmung zwischen den entsprechenden Messwerten und der Ökotoxizitat ermittelt wurde; (iv) die Kinetik ausgewählter PCĄ-Parameter (Agglomerationsverhalten; ZetaĄ-Potential, Reaktivität, Löslichkeit) im Test. Ferner wird eine größere Anzahl an ECĄ-Werten benötigt, um die Aussagekraft der Statistik zu erhöhen. Quelle: Forschungsberichtde
dc.description.abstractThe project aimed at the development of a concept for the grouping of engineered nanomaterials (NMs) with regard to their ecotoxicological effects on algae, daphnids and fish embryos. The project was structured into five steps. First, fourteen nanomaterials were selected which were. Different subtypes of Ag, ZnO, TiO2, CeO2 and Cu. In a second step, their physicoĄ-chemical properties were determined in water and in all relevant test media. Based on these results hypotheses regarding the expected ecotoxicity were formulated (third step). In a fourth step, the hypotheses were verified by testing the selected NMs in three aquatic ecotoxicological tests. Finally, step five consisted of the compilation of a grouping concept based on NM physicoĄ-chemical parameters which were identified as relevant for the emergence of a toxic effect in aquatic organisms. Based on the results of the measurements and expert knowledge, morphology, stability (ion release, crystalline structure) were identified as relevant PCĄ-parameters. A grouping scheme and procedure was proposed considering these parameters and the ecotoxicity of the chemical composition itself. It was realized that it is impossible to build meaningful grouping hypotheses based on one physico-chemical parameter. Rather, sets of parameters, and probably also additional physicoĄ-chemical parameters next to those investigated in this project need to be considered. In order to further advance grouping concepts for regulatory testing, future developments with respect to research on grouping concepts should include (i) surface modifications which were excluded in the present project, (ii) the substitution of the fish embryo test which reveals to be of low sensitivity, (iii) adaptation of the methods for the determination of the reactivity as no relationship between ecotoxicity and the results of the applied methods on reactivity were observed, (iv) a detailed analysis of the kinetic of selected PCĄ-parameters during the tests such as agglomeration behavior, zetaĄ]potential, reactivity and solubility. Furthermore, (v) the number of effect values per NM and test organism has to be increased to achieve more robust datasets for statistical analyses. Quelle: Forschungsberichten
dc.description.abstractBased on the variety of existing nanomaterials with numerous modifications, the effort of investigating environmental fate and effects will be tremendous. Hence, it will be necessary to group nanomaterials which feature similar environmental fate and effects.  Therefore, the project objective was to correlate physical-chemical data with ecotoxicological effects for selected nanomaterials and to define reference values which can serve as a basis for grouping. The report presents the development of concepts for grouping of nanomaterials with regard to their ecotoxicological effects with focus on aquatic ecotoxicity. The project was structured into five steps. First, fourteen nanomaterials were selected according to pre-defined criteria. The selected NMs were different subtypes of Ag, ZnO, TiO2, CeO2 and Cu. In a second step, their physico-chemical properties were determined in water and in all test media. Based on the results hypotheses regarding the expected ecotoxicity were formulated (third step). In a fourth step, the hypotheses were verified by testing the selected NMs in three ecotoxicological tests (acute aquatic toxicity with algae, daphnia and fish embryo according to the ⁠OECD⁠ Test Guidelines No. 201, 202 and 236). Finally, step five consisted of the compilation of a grouping concept based on nanomaterials physico-chemical parameters which were identified as relevant for the emergence of a toxic effect in aquatic organisms.en
dc.format.extent1 Onlineressource (91 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-5927
dc.identifier.urihttps://openumwelt.de/handle/123456789/6505
dc.language.isoeng
dc.publisherUmweltbundesamt
dc.relation.ispartofseriesTexte
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectNanomaterialien
dc.subjectRegulierung
dc.subjectÖkotoxikologie
dc.subjectKlassifikation
dc.subjectStoffbewertung
dc.subjectPrüfverfahren
dc.subjectUmweltauswirkung
dc.subjectSchadstoffverhalten
dc.subjectGesetzesvollzug
dc.subjectÖkotoxizität
dc.subjectgrouping
dc.subjectnanomaterials
dc.subjectaquatic ecotoxicology
dc.subject.ubaThemeChemicals
dc.titleConsiderations about the relationship of nanomaterial´s physical-chemical properties and aquatic toxicity for the purpose of grouping
dc.title.alternativeConsiderations about the relationship of nanomaterial´s physical-chemical properties and aquatic toxicity for the purpose of grouping
dc.typeForschungsbericht
dc.typeMonographie
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.number102/2017
local.bibliographicCitation.publisherPlaceDessau-Roßlau
local.collectionTexte / Umweltbundesamt
local.contributor.authorId02078901
local.contributor.authorId02140448
local.contributor.authorId02166504
local.contributor.otherId02122542
local.identifier.catalogId02452057
local.identifier.cmsId59270
local.identifier.fundingIndicator3714674170
local.identifier.standardizedFundingIndicator37146741
local.ingest.catalogBCnumber102/2017
local.ingest.cmsBCnumber102/2017
local.ingest.cmsCreatedOn2017-11-07T15:11:46
local.ingest.cmsModifiedOn2017-11-22T14:16:37
local.ingest.cmsStateChangedOn2017-11-22T14:16:36
local.ingest.cmsStateNewLive (veröffentlicht)
local.ingest.cmsStateOldzur Freigabe
local.ingest.cmsStateRevisionId102191
local.ingest.leader11875nam a2200000uu 4500
local.jointTitleCONSIDERATIONS ABOUT THE RELATIONSHIP OF NANOMATERIALS PHYSICALCHEMICAL PROPERTIES AND AQUATIC TOXICITY FOR THE PURPOSE OF GROUPING FINAL REPORT
local.newsletter0
local.sourcecatalog
local.sourceenriched with cms, Id: 59270 at 2024-06-18T15:52:41.985866
local.source.urihttp://webde/gruppen/bibliothek/OnlineReports/EF000973-ENG.pdf
local.subject.researchIndicator67
local.subtitlefinal Report
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