Method development for analysis of pharmaceuticals in environmental samples

Abstract

Die Verbreitung von Arzneimittel in Gewässern und deren Gefährdungspotential für Wasserlebewesen hat in den letzten Jahren beunruhigende Ausmaße angenommen. Immer mehr Arzneimittel werden in Konzentrationen bis in den unteren ug/L-Bereich in der aquatischen Umwelt nachgewiesen. Vor diesem Hintergrund ist das Ziel dieses Projekts analytische Nachweisverfahren und Probenahmekonzepte für ausgewählte Arzneimittel und verschiedene Matrizes (Wasser, Sediment, Schwebstoff, Biota) zu entwickeln, optimieren, validieren und vergleichen. Leistungsstarke LC-MS-MS Methoden wurden für den Nachweis von extrem polaren, polaren und hormonellen Arzneimitteln in Wasserproben entwickelt und validiert. Mit Hilfe dieser Methoden wurden dann das Vorkommen und die Verteilung der ausgewählten Arzneimittel in Wasserproben aus Gewässern mit unterschiedlichen Abwasseranteilen ermittelt. Für die Analytik von Schwebstoff- und Biotaproben wurden Extraktions- und Aufreinigungsverfahren getestet, allerdings befinden sich diese Methoden noch in der Entwicklung. Des Weiteren wurde ein Monitoringskonzept entwickelt und Wasser-, Schwebstoff und Biotaproben aus sechs verschiedenen Gewässern entnommen. Quelle: Forschungsbericht

Since the last decades the increasing currency of pharmaceuticals in the aquatic environment and their risk potential for the aquatic life has become an urgent issue. The number of pharmaceuticals detectable in the low ug/L range in the environment is rising each day. Against this background the aim of this project was the development, optimization, validation and comparison of analytical methods for quantification of selected pharmaceuticals in different environmental matrices (water, sediment, suspened particular matter and biota). High sensitive LC-MS-MS methods for determination of extreme polar, polar and hormonal pharmaceuticals in water samples were developed and validated. Using these methods occurrence and distribution of the selected pharmaceuticals in water with different waste water content were determined. For analysis of pharmaceuticals in particular matter and biota samples extraction and clean-up procedures were tested, but method development is still in process. Furthermore a monitoring campaign was set up and water samples, suspended particular matter and biota (fish) samples from six different sampling sites were taken. Quelle: Forschungsbericht Modalität Abstract übernommen

Since the last decades the increasing currency of pharmaceuticals in the aquatic environment and their risk potential for the aquatic life has become an urgent issue. The number of pharmaceuticals detectable in the low μg/L range in the environment is rising each day. Against this background the aim of this project was the development, optimization, validation and comparison of analytical methods for quantification of selected pharmaceuticals in different environmental matrices (water, sediment, suspended particular matter and biota). High sensitive LC-MS-MS methods for determination of extreme polar, polar (see also Boulard et al.) and hormonal pharmaceuticals (see also Weizel et al.) in water samples were developed and validated. Using these methods occurrence and distribution of the selected pharmaceuticals in water with different wastewater content were determined. For analysis of pharmaceuticals in particular matter and biota samples extraction and clean-up procedures were tested, but method development is still in process. Furthermore a monitoring campaign was set up and water samples, suspended particular matter and biota (fish) samples from six different sampling sites were taken.During the project 2 articles have been published: Boulard et al. (DOI: 10.1016/j.chroma.2017.12.023) and Weizel at al. (DOI: 10.1021/acs.est.7b06147).