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A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes

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dc.contributor.authorKeminer, Oliver
dc.contributor.authorArning, Jürgen
dc.contributor.authorTeigeler, Matthias
dc.contributor.authorKohler, Manfred
dc.date.accessioned2024-06-16T13:56:18Z
dc.date.available2024-06-16T13:56:18Z
dc.date.issued2020
dc.description.abstractBisphenol A (BPA) is a high production volume chemical with a broad application spectrum. As an endocrine disrupting chemical, mainly by modulation of nuclear receptors (NRs), BPA has an adverse impact on organisms and is identified as a substance of very high concern under the European REACH regulation. Various BPA substitution candidates have been developed in recent years, however, information concerning the endocrine disrupting potential of these substances is still incomplete or missing. In this study, we intended to investigate the endocrine potential of BPA substitution candidates used in environmentally relevant applications such as thermal paper or epoxy resins. Based on an extensive literature and patent search, 33 environmentally relevant BPA substitution candidates were identified. In order to evaluate the endocrine potential of the BPA replacements, a screening cascade consisting of biochemical and cell-based assays was employed to investigate substance binding to the NRs estrogen receptor ÎÌ and Î2, as well as androgen receptor, co-activator recruitment and NR-mediated reporter gene activation. In addition, a computational docking approach for retrospective prediction of receptor binding was carried out. Our results show that some BPA substitution candidates, for which so far no or only very few data were available, possess a substantial endocrine disrupting potential (TDP, BPZ), while several substances (BPS, D-8, DD70, DMP-OH, TBSA, D4, CBDO, ISO, VITC, DPA, and DOPO) did not reveal any NR binding. © 2019 The Author(s).en
dc.format.extent1 Onlineresource (12 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-172
dc.identifier.urihttps://openumwelt.de/handle/123456789/3913
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBisphenol A
dc.titleA tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes
dc.title.alternativeA tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleThe Science of the Total Environment
local.bibliographicCitation.originalDOI10.1016/j.scitotenv.2019.134743
local.bibliographicCitation.volume717 (2020)
local.collectionAufsätze
local.contributor.authorId02180124
local.contributor.authorId02105737
local.contributor.authorId02184921
local.identifier.catalogId02479885
local.ingest.leader05302naa a2200000uu 4500
local.jointTitleA TIERED HIGHTHROUGHPUT SCREENING APPROACH FOR EVALUATION OF ESTROGEN AND ANDROGEN RECEPTOR MODULATION BY ENVIRONMENTALLY RELEVANT BISPHENOL A SUBSTITUTES
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relation.isAuthorOfPublication.latestForDiscoverybb1c163d-200c-4bce-b0c9-31a04141c392
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