Person: Weber, Till
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Veröffentlichung Die Umweltprobenbank des Bundes - Umwelt- und Humanproben(2019) Kolossa-Gehring, Marike; Körner, Andrea; Koschorreck, Jan; Rüther, Maria; Weber, TillDie Umweltprobenbank des Bundes sammelt standardisiert Human- und Umweltproben und lagert diese veränderungsfrei für zukünftige Untersuchungen. Die große Auswahl an unterschiedlichen Matrizes aus verschiedenen Probenahmegebieten ermöglicht einen Überblick über die Belastungssituation des Menschen und seiner Umwelt. Die Schadstoffanalytik erfolgt sowohl im direkten Anschluss an die Probenahme (Real-Time-Monitoring) als auch in retrospektiven Untersuchungen an den eingelagerten Proben. Die hohe Standardisierung ermöglicht die Reproduzier- und Vergleichbarkeit der gesammelten Proben und lässt so eine Aussage über die zeitliche Veränderung der Belastungen zu. Die Umweltprobenbank des Bundes ist ein exzellentes Werkzeug für das Monitoring der Schadstoffbelastungen der Umwelt und des Menschen. Geringe zeitliche oder marginale regionale Unterschiede an Schadstoffkonzentrationen sind erfassbar, da die hierzu notwendigen Analysen standardisierter Umwelt- und Humanproben aus unterschiedlichen Jahren und Regionen zum gleichen Zeitpunkt durchgeführt werden können. Die Langzeitbeobachtung von Schadstoffbelastungen in Umwelt- und Humanproben ist eine wichtige Grundlage für gesetzliche Regulierungen von Chemikalien und deren Erfolgskontrolle. Damit ist die Umweltprobenbank des Bundes ein essenzielles Instrument des umweltbezogenen Gesundheitsschutzes in Deutschland. Quelle: http://www.ecomed-medizin.deVeröffentlichung Internal exposure of young German adults to di(2-propylheptyl) phthalate (DPHP): Trends in 24-h urine samples from the German Environmental Specimen Bank 1999-2017(2019) Schmidtkunz, Christoph; Gries, Wolfgang; Kolossa-Gehring, Marike; Weber, TillDi(2-propylheptyl) phthalate (DPHP) is used as a substitute for high molecular weight phthalates like di(2-ethylhexyl) phthalate (DEHP) which were subjected to authorization under REACh in 2015. An earlier study on the time trend of exposure in human 24-h urine samples from the German Environmental Specimen Bank has revealed that metabolites of DPHP emerged in 2009 and 2012 (Schütze et al., 2015). In order to better assess a potential trend and the present state of exposure to DPHP, we now measured 180 urine samples from the German Environmental Specimen Bank, 60 per year, collected in 2011, 2014 and 2017, randomized and blinded before analysis. Together with the previously analyzed samples, data for a total of 480 samples covering 19 years from 1999 to 2017 was thus generated. We were able to show that DPHP exposure of the studied population, university students from Münster (Northwestern Germany), has remained essentially constant since 2011, after a rapid increase starting around 2009. Even so, urinary metabolite concentrations were always in the low ppb or sub-ppb range, indicating that DPHP exposure of the general population is substantially lower than for other modern plasticizers, and far below levels currently regarded as critical. DPHP is a plasticizer which is mostly used in non-sensitive applications with little probability of close contact to humans. Still, we observed how temporal trends of DPHP exposure largely follow trends of DPHP consumption in the Western European market. Our results hence demonstrate the potential of biomonitoring to sensitively detect the effects of industrial product strategy on the environment, even when biomarkers are present only at trace level. © 2019 Elsevier GmbH. All rights reserved.Veröffentlichung Time-trends of the German population exposure to contaminants using the part for human samples of the German Environmental Specimen Bank (ESB)(2017) Conrad, André; Lermen, D.; Kolossa-Gehring, Marike; Hildebrand, J.; Rüther, Maria; Weber, TillVeröffentlichung Trends in characteristics of 24-h urine samples and their relevance for human biomonitoring studies - 20 years of experience in the German Environmental Specimen Bank(2019) Lermen, Dominik; Bartel-Steinbach, Martina; Conrad, André; Gwinner, Frederik; Kolossa-Gehring, Marike; Weber, TillTo document trends in human exposure to environmental pollutants, the German Environmental Specimen Bank (ESB) has been routinely collecting and archiving 24-h urine samples from young adults at four sampling sites in Germany on an annual basis. For the purpose of normalizing measured analyte concentrations, urinary creatinine (UC), specific gravity (SG), conductivity (CON), and total urine volume (UVtot) of 24-h urine samples have also been recorded. These parameters are however susceptible to variation over time, as well as within/among participants and normalization against them can thus affect the interpretation of data regarding exposure to environmental pollutants. To evaluate the influence of normalization against these parameters, we first sought to determine variations of these parameters with regard to differences between sexes and trends over time. We analysed data from 8619 urine samples collected from 1997 to 2016. We observed an inverse relation between UVtot and UC, SG, and CON. We also found differences between sexes for UC, SG and CON, but not UVtot. UC, SG, and CON showed significant decreasing trends over time in both sexes. In contrast, a significant increase of over 30% in UVtot, independent of participant age and BMI, was revealed. This increase in UVtot and the concomitant sample dilution is likely to have an impact on measured analyte concentrations in 24-h urine samples. Hence, normalization of urinary concentrations is warranted when interpreting time trends of human exposure. Next, urinary calcium (Ca2+) concentrations of ESB participants were used to demonstrate the effects of normalization against each of the four urine parameters. From 1997 to 2016, measured Ca2+ concentrations showed a statistically significant but scientifically implausible decrease. Normalization of Ca2+ concentrations against UVtot (by calculating the total daily excretion), UC, or CON, but not SG, eliminated this decrease. Consistent with previous work, Ca2+ concentrations in urine and total daily Ca2+ excretion were higher for males than females. Normalization against UC, SG, or CON, however, attenuated this difference. Thus, to avoid misinterpretation in trend analysis and sex-specific excretion in 24-h urine samples, the calculation of the total daily excretion is recommended.Veröffentlichung Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014(2018) Ulrich, Nadin; Bury, Daniel; Koch, Holger Martin; Kolossa-Gehring, Marike; Rüther, Maria; Weber, TillPurpose The aim of this study was to get a first overview of the exposure to the solvents and reproductive toxicants N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) in Germany. NMP and NEP metabolite concentrations were determined in 540 24-h urine samples of the German Environmental Specimen Bank collected from 1991 to 2014. With these data we were able to investigate NMP/NEP exposures over time and to evaluate associated risks. Methods NMP metabolites 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) and NEP metabolites 5-hydroxy-N-ethyl-2-pyrrolidone (5-HNEP) and 2-hydroxy-N-ethylsuccinimide (2-HESI) were determined by stable isotope dilution analysis using solid phase extraction followed by derivatization (silylation) and GCâ€ÌEIâ€ÌMS/MS. Results We were able to quantify 5-HNMP and 2-HMSI in 98.0 and 99.6% and 5-HNEP and 2-HESI in 34.8 and 75.7% of the samples. Metabolite concentrations were rather steady over the timeframe investigated, even for NEP which has been introduced as an NMP substitute only in the last decade. Calculated median daily intakes in 2014 were 2.7 Ìg/kg bw/day for NMP and 1.1 Ìg/kg bw/day for NEP. For the combined risk assessment of NMP and NEP exposure, the hazard index based on the human biomonitoring assessment I values (HBM I values) was less than 0.1. Conclusions Based on the investigated subpopulation of the German population, individual and combined NMP and NEP exposures were within acceptable ranges in the investigated timeframe. Sources of NEP exposure in the 90s and 00s remain elusive. © Springer-Verlag GmbH Germany, part of Springer Nature 2018