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Veröffentlichung A call for urgent action to safeguard our planet and our health in line with the helsinki declaration(2021) Halonen, Jaana I.; Erhola, Marina; Furman, Eeva; Kolossa-Gehring, MarikeIn 2015, the Rockefeller Foundation-Lancet Commission launched a report introducing a novel approach called Planetary Health and proposed a concept, a strategy and a course of action. To discuss the concept of Planetary Health in the context of Europe, a conference entitled: "Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health" was held in Helsinki in December 2019. The conference participants concluded with a need for action to support Planetary Health during the 2020s. The Helsinki Declaration emphasizes the urgency to act as scientific evidence shows that human activities are causing climate change, biodiversity loss, land degradation, overuse of natural resources and pollution. They threaten the health and safety of human kind. Global, regional, national, local and individual initiatives are called for and multidisciplinary and multisectorial actions and measures are needed. A framework for an action plan is suggested that can be modified for local needs. Accordingly, a shift from fragmented approaches to policy and practice towards systematic actions will promote human health and health of the planet. Systems thinking will feed into conserving nature and biodiversity, and into halting climate change. The Planetary Health paradigm - the health of human civilization and the state of natural systems on which it depends - must become the driver for all policies. Quelle: © Elsevier 2021Veröffentlichung Krankheitslast in Deutschland und seinen Regionen(2022) Porst, Michael; Lippe, Elena von der; Leddin, Janko; Gruhl, Heike; Plaß, DietrichHintergrund: Summenmaße wie die "disability-adjusted life years" (DALY) werden zur standardisierten Erfassung der Krankheitslast durch Tod und gesundheitliche Einschränkungen zunehmend bedeutsamer. Das Projekt BURDEN 2020 zielte darauf ab, auf Grundlage nationaler Daten eine eigenständige Krankheitslaststudie für Deutschland mit kleinräumigen Schätzungen als Pilotprojekt durchzuführen. Methode: DALY sind die Summe aus "durch Sterblichkeit verlorene Lebensjahre" ("years of life lost due to death" [YLL]) und "mitgesundheitlichen Einschränkungen oder in Krankheit verbrachte Lebensjahre" ("years lived with disability" [YLD]). Während YLL den Abstand zwischen Todesalter und fernerer Lebenserwartung beschreiben, quantifizieren YLD die Jahre, die mit gesundheitlichen Einschränkungen verbracht werden. Als Datenquellen dienen vor allem die Todesursachenstatistik, Befragungsdaten und Krankenkassenroutinedaten. Ergebnisse: Für Deutschland ergaben sich im Jahr 2017 rund 12 Millionen DALY, umgerechnet 14 584 DALY je 100 000 Einwohner. An der Rate gemessen trug die koronare Herzkrankheit insgesamt (2 321 DALY) am meisten zur Krankheitslast bei, gefolgt von Schmerzen im unteren Rücken (1 735 DALY) und Lungenkrebs (1 197 DALY). Bei Frauen verursachten Kopfschmerzerkrankungen und Demenzen mehr Krankheitslast als bei Männern. Männer hatten eine höhere Krankheitslast durch Lungenkrebs oder alkoholbezogene Störungen. Die Schmerzerkrankungen sowie alkoholbezogene Störungen führten bei beiden Geschlechtern im jüngeren Erwachsenenalter die DALY-Rangfolgen an. Mit dem Alter stieg die Krankheitslast für einen Teil der Erkrankungen, einschließlich der kardiovaskulären Erkrankungen, Demenzen oder Diabetes mellitus. Teilweise zeigte die Krankheitslast unterschiedliche regionale Verteilungen. Schlussfolgerung: Die Ergebnisse deuten auf alters- und geschlechtsspezifische Präventions- sowie kleinräumige Versorgungsbedarfe hin. Krankheitslaststudien liefern umfassende Daten zur Surveillance der Bevölkerungsgesundheit und können gesundheitspolitische Entscheidungen unterstützen. © AuthorsVeröffentlichung Europäische Human-Biomonitoring Initiative erfolgreich abgeschlossen(2022) Apel, Petra; Kolossa-Gehring, Marike; Lange, Rosa; Pack, Kim Laura; Reiber, Lena; Weise, Philipp2017 wurde die Europäische Human Biomonitoring Initiative (HBM4EU) mit dem Ziel gestartet, die Schadstoffbelastung der EU Bevölkerung systematisch zu erfassen. Die Belastungen der europäischen Bevölkerung mit einer Vielzahl von Umweltschadstoffen wurden erstmals vergleichbar ermittelt, bewertet und bereitgestellt. Die Ergebnisse zeigen, dass die Belastungen der EU-Bevölkerung mit vielen Schadstoffen, wie etwa bestimmten Weichmachern und per- und polyfluorierten Alkylsubstanzen (PFAS), zu hoch sind, und gesundheitliche Beeinträchtigungen nicht mit ausreichender Sicherheit ausgeschlossen werden können. Die Erkenntnisse werden an die politischen Entscheidungsträger weitergegeben und sollen bei der Verbesserung der Chemikalien-, Umwelt- und Gesundheitspolitik unterstützen, sodass letztlich gesundheitsrelevante chemische Belastungen minimiert werden. Der folgende Artikel gibt eine Übersicht über die wichtigsten Projektergebnisse. Quelle: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz / Boden- und Lufthygiene (Berlin) Institut für Wasser- - (2022), Heft 02, Seite 41Veröffentlichung HBM4EU results support the Chemicals' Strategy for Sustainability and the Zero-Pollution Action Plan(2023) Vicente, Joana Lobo; David, Madlen; Ganzleben, Catherine; Gasol, Roser; Gerofke, Antje; Kolossa-Gehring, MarikeOne of the major goals of the European Human Biomonitoring Initiative (HBM4EU) was to bridge the gap between science and policy by consulting both policy makers and national scientists and generating evidence of the actual exposure of residents to chemicals and whether that exposure would be suggest a potential health risk. Residents' perspectives on chemical exposure and risk were also investigated. HBM4EU's research was designed to answer specific short-term and long-term policy questions at national and European levels, and for its results to directly support regulatory action on chemicals. A strategy was established to prioritise chemicals for analysis in human matrices, with a total of 18 substances/substance groups chosen to be investigated throughout the five-and a -half-year project. HBM4EU produced new evidence of human exposure levels, developed reference values for exposure, investigated determinants of exposure and derived health-based guidance values for those substances. In addition, HBM4EU promoted the use of human biomonitoring data in chemical risk assessment and developed innovative tools and methods linking chemicals to possible health impacts, such as effect biomarkers. Furthermore, HBM4EU advanced understand of effects from combined exposures and methods to identify emerging chemicals. With the aim of supporting policy implementation, science-to-policy workshops were organised, providing opportunities for joint reflection and dialogue on research results. I, and indicators were developed to assess temporal and spatial patterns in the exposure of European population. A sustainable human biomonitoring monitoring framework, producing comparable quality assured data would allow: the evaluation of time trends; the exploration of spatial trends: the evaluation of the influence of socio-economic conditions on chemical exposure. Therefore, such a framework should be included in the European Chemicals' Strategy for Sustainability and the data would support the Zero Pollution Action Plan. © 2023 The AuthorsVeröffentlichung The burden of disease in Germany at the national and regional Level(2022) Porst, Michael; Lippe, Elena von der; Leddin, Janko; Gruhl, Heike; Plaß, DietrichBackground: Summary measures such as disability-adjusted life years (DALY) are becoming increasingly important for the standardized assessment of the burden of disease due to death and disability. The BURDEN 2020 pilot project was designed as an independent burden-of-disease study for Germany, which was based on nationwide data, but which also yielded regional estimates. Methods: DALY is defined as the sum of years of life lost due to death (YLL) and years lived with disability (YLD). YLL is the difference between the age at death due to disease and the remaining life expectancy at this age, while YLD quantifies the number of years individuals have spent with health impairments. Data are derived mainly from causes of death statistics, population health surveys, and claims data from health insurers. Results: In 2017, there were approximately 12 million DALY in Germany, or 14 584 DALY per 100 000 inhabitants. Conditions which caused the greatest number of DALY were coronary heart disease (2321 DALY), low back pain (1735 DALY), and lung cancer (1197 DALY). Headache and dementia accounted for a greater disease burden in women than in men, while lung cancer and alcohol use disorders accounted for a greater disease burden in men than in women. Pain disorders and alcohol use disorders were the leading causes of DALY among young adults of both sexes. The disease burden rose with age for some diseases, including cardiovascular diseases, dementia, and diabetes mellitus. For some diseases and conditions, the disease burden varied by geographical region. Conclusion: The results indicate a need for age- and sex-specific prevention and for differing interventions according to geographic region. Burden of disease studies yield comprehensive population health surveillance data and are a useful aid to decision-making in health policy. © Authors