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Deutsch, Markus

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Deutsch

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Markus

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Deutschland, Umweltbundesamt, Fachgebiet IV.1.3 - Pflanzenschutzmittel

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20222

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  • Vorschaubild nicht verfügbar
    Veröffentlichung
    Correction: a critical review of bioaccumulation and biotransformation of organic chemicals in birds
    (2022) Kuo, Dave T. F.; Deutsch, Markus; Rattner, Barnett A.; Marteinson, Sarah C.; Treu, Gabriele
    The article A Critical Review of Bioaccumulation and Biotransformation of Organic Chemicals in Birds, was originally published electronically on the publisher's Internet portal on 9 April 2021 without open access. With the author(s) decision to opt for Open Choice the copyright of the article changed on 25 July 2022 to © The Author(s) 2022 and the article is forthwith distributed under a Creative Commons Attribution. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp:// creat iveco mmons. org/ licen ses/ by/4. 0/. The original article has been revised due to retrospective Open access order. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. © Elsevier 2022
  • Vorschaubild nicht verfügbar
    Veröffentlichung
    A critical review of bioaccumulation and biotransformation of organic chemicals in birds
    (2022) Kuo, Dave T. F.; Deutsch, Markus; Rattner, Barnett A.; Marteinson, Sarah C.; Treu, Gabriele
    A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research. The objectives were to characterize available bioaccumulation/biotransformation data, identify knowledge gaps, determine how extant data can be used, and explore the strategy and steps forward. An intermediate approach balanced between expediency and rigor was taken given the vastness of the literature. Following a critical review of [500 peer-reviewed studies, [25,000 data entries and 2 million information bytes were compiled on [700 organic compounds for * 320 wild species and 60 domestic breeds of birds. These data were organized into themed databases on bioaccumulation and biotransformation, field survey, microsomal enzyme activity, metabolic pathway, and bird taxonomy and diet. Significant data gaps were identified in all databases at multiple levels. Biotransformation characterization was largely fragmented over metabolite/pathway identification and characterization of enzyme activity or biotransformation kinetics. Limited biotransformation kinetic data constrained development of an avian biotransformation model. A substantial shortage of in vivo biotransformation kinetics has been observed as most reported rate constants were derived in vitro. No metric comprehensively captured all key contaminant classes or chemical groups to support broad-scope modeling of bioaccumulation or biotransformation. However, metrics such as biota-feed accumulation factor, maximum transfer factor, and total elimination rate constant were more readily usable for modeling or benchmarking than other reviewed parameters. Analysis demonstrated the lack of bioaccumulation/biotransformation characterization of shorebirds, seabirds, and raptors. In the study of bioaccumulation and biotransformation of organic chemicals in birds, this review revealed the need for greater chemical and avian species diversity, chemical measurements in environmental media, basic biometrics and exposure conditions, multiple tissues/matrices sampling, and further exploration on biotransformation. Limitations of classical bioaccumulation metrics and current research strategies used in bird studies were also discussed. Forward-looking research strategies were proposed: adopting a chemical roadmap for future investigations, integrating existing biomonitoring data, gap-filling with non-testing approaches, improving data reporting practices, expanding field sampling scopes, bridging existing models and theories, exploring biotransformation via avian genomics, and establishing an online data repository. The Author(s) 2022