Publikation:
DPHP metabolites in urine samples of the German Environmental Specimen Bank from 1999 to 2012

Kurzanzeige
dc.contributor.otherSchütze, Andre
dc.contributor.otherGries, Wolfgang
dc.contributor.otherKolossa-Gehring, Marike
dc.contributor.otherApel, Petra
dc.contributor.otherSchröter-Kermani, Christa
dc.contributor.otherBrühning, Thomas
dc.contributor.otherLeng, Gabriele
dc.contributor.otherKoch, Holger Martin
dc.date.accessioned2024-06-16T16:21:58Z
dc.date.available2024-06-16T16:21:58Z
dc.date.issued2014
dc.description.abstractThe aim of this study was to investigate a possible time trend and status quo of<BR>dipropylheptylphthalate (DPHP) exposure. DPHP is used as a substitute of other high molecular weightphthalates in high temperature applications (e.g cable wires, roofing membranes, etc.). DPHP was selected inthe cooperation project between the German Federal Ministry for Environment (BMU) and the German ChemicalIndustry Association (VCI) due to its listing as High Production Volume (HPV) chemical in the European Union.The BMU-VCI project establishes new human biomonitoring methods and biomarkers for fifty emergingsubstances. 300 urine samples (24-hour voids) from the German Environmental Specimen Bank were analyzedfor three specific, secondary oxidized DPHP metabolites (with hydroxyl, oxo and carboxy modifications of thealkyl side chain). Urine samples were collected in the years 1999, 2003, 2006, 2009 and 2012, 60 samples peryear, from 30 male and 30 female volunteers (age: 21-29 years). The samples were analyzed by liquid/liquidextraction followed by GC-HRMS, which enabled us to distinguish between DPHP and Di-iso-decyl phthalate(DiDP) metabolites. The limit of quantification was between 0.15 ìg/l and 0.3 ìg/l, depending on the metabolite.All samples were blinded before analysis. DPHP metabolites were not detected in the years 1999-2006.Thereafter, detection rates increased from 3.3% in 2009 to 21.7% in 2012. As expected, mono-oxo-propylheptylphthalate (oxo-MPHP) was the most abundant metabolite, with concentrations between <LOQ and 0.96 ìg/l.The daily DPHP intake was calculated via oxo-MPHP with a maximum of 0.32 ìg/kg bodyweight/day. Ourresults show that DPHP exposure has reached the general German population. However, exposure to DPHP isconsiderably lower than for other high molecular weight phthalates. Future measurements will enable us tomonitor the development of DPHP exposure and advise risk management steps, if warranted.<BR>Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.128en
dc.format.extent19 Vortragsfolien
dc.format.extentgraph. Darst.
dc.identifier.urihttps://openumwelt.de/handle/123456789/8580
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleDPHP metabolites in urine samples of the German Environmental Specimen Bank from 1999 to 2012
dc.typeConference proceedings
dc.typeMonographie
dspace.entity.typePublication
local.bibliographicCitation.conference24th annual meeting of International Society of Exposure Science
local.collectionRede
local.contributor.otherId02157262
local.contributor.otherId02165863
local.contributor.otherId00400713
local.contributor.otherId02054215
local.contributor.otherId02065957
local.contributor.otherId02165864
local.contributor.otherId00341949
local.contributor.otherId02110258
local.identifier.catalogId02412804
local.ingest.leader05953nam a2200000uu 4500
local.jointTitleDPHP METABOLITES IN URINE SAMPLES OF THE GERMAN ENVIRONMENTAL SPECIMEN BANK FROM 1999 TO 2012
local.sourcecatalog
local.source.urihttp://webde/Gruppen/bibliothek/NBM/VO000365.pdf
local.staffPublicationtrue
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