Publikation:
New biomarkers for DPHP, 2-MBT and MDI

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dc.contributor.otherGries, Wolfgang
dc.contributor.otherLeng, Gabriele
dc.contributor.otherKolossa-Gehring, Marike
dc.contributor.otherFiddicke, Ulrike
dc.date.accessioned2024-06-16T16:01:54Z
dc.date.available2024-06-16T16:01:54Z
dc.date.issued2015
dc.description.abstract1. Analytical determination of specific 4,4- Methylenediphenyl-diisocyanate (MDI) hemoglobin adducts: MDI is one of the most important isocyanates in the industrial production of polyurethane and other MDI based synthetics. Because of its reactivity it builds adducts with proteins. Analysis of MDI is routinely done by determination of 4,4-methylene dianiline as marker for MDI exposure in urine and blood. This procedure does not allow distinguishing between the source of exposure; MDA or MDI. This method was developed to detect the MDI specific hemoglobin adduct 5-isopropyl-3[4-(4-aminobenzyl)phenyl] hydantoin in human blood. <BR>2. Analytical method for the selective determination of major Di-(2-propylheptyl)-phthalate (DPHP) metabolites in human urine: DPHP is a specific phthalic acid ester of isomeric C10 alcohols and is marketed as plasticizer for polyvinyl chloride . The object of this method development is the sensitive and selective determination of the three major DPHP metabolites mono-2-(propyl-6-hydroxy-heptyl)-phthalate, mono-2-(propyl-6-oxoheptyl)-phthalate and mono-2-(propyl-6-carboxy-hexyl)-phthalate in human urine among those originating from DIDP or DINP. Values up to 3.8 ìg/L OH-MPHP were detected in 51 urines of children during the "Pilot Phase of the 5th German Environmental Survey-Part 1Ł. <BR>3. Rapid and sensitive LC-MS/MS determination of 2-Mercaptobenzothiazole (MBT) in human urine: MBT is one of the most important vulcanization accelerators in the industrial production of rubber. Incorporated MBT is excreted in urine mainly as conjugates. A method was developed to determine the internal MBT dose in human urine. Total MBT is measured after enzymatic hydrolysis followed by application of high pressure liquid chromatography tandem mass spectrometry in positive electrospray ionization mode. In the "Pilot Phase of the 5th German Environmental Survey-Part 1Ł MBT vThe International Societyof Exposure Science: 25th Annual Meeting: Exposures in an Evolving Environment; October 18 - 22, 2015 - Henderson, Nevada, S. alues up to 5.95 ìg/L were analyzed in 51 urines of children.<BR>In: The International Societyof Exposure Science: 25th Annual Meeting: Exposures in an Evolving Environment; October 18 - 22, 2015 - Henderson, Nevada, S.137en
dc.format.extent20 Vortragsfolien
dc.format.extentgraph. Darst.
dc.identifier.urihttps://openumwelt.de/handle/123456789/7748
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiomonitoring
dc.titleNew biomarkers for DPHP, 2-MBT and MDI
dc.typeConference proceedings
dc.typeMonographie
dspace.entity.typePublication
local.bibliographicCitation.conference25th annual meeting of the International Society of Exposure Science (ISES)
local.collectionRede
local.contributor.otherId02165863
local.contributor.otherId00341949
local.contributor.otherId00400713
local.contributor.otherId02146005
local.identifier.catalogId02430996
local.ingest.leader05128nam a2200000uu 4500
local.jointTitleNEW BIOMARKERS FOR DPHP 2MBT AND MDI
local.sourcecatalog
local.staffPublicationtrue
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