Publikation:
Cumulative risk assessment of five phthalates in European children and adolescents

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dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorLange, Rosa
dc.contributor.authorGerofke, Antje
dc.contributor.authorSchmidt, Philipp
dc.contributor.authorVogel, Nina
dc.date.accessioned2024-06-16T13:09:21Z
dc.date.available2024-06-16T13:09:21Z
dc.date.issued2022
dc.description.abstractThe European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called "HBM4EU Aligned Studies" revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, thus, a mixture risk assessment is warranted. In our study, we determine the risk from combined exposure to five anti-androgenic phthalates, namely DEHP, DiBP, DnBP, BBzP and DiNP by making use of the hazard index (HI) approach. Toxicologically-based human biomonitoring guidance values (HBM-GVs) derived within the framework of HBM4EU served as basis. Our results show that exposures of 17% of children and adolescents from twelve European countries resulted in hazard indices (HI)>1 with an HI of 1.77 at the 95th percentile (geometric mean, GM=0.44). Main drivers for the mixture risk are DnBP and DiBP. Generalized Linear Model (GLM) analysis including four major exposure determinants (age, sex, European region, sampling year) simultaneously reveal differences for the European regions and between sampling years. Children and adolescents living in the Eastern region of Europe have on average, higher HIs (GM=0.58) than in the Southern region (GM=0.36) and Western region (GM=0.42). Moreover, participants from which urine samples were taken in the earlier years (2014-2016) seem to have higher average HI levels than participants from studies with later sampling periods. Strikingly, the majority (63%) of participants with HIs>1 would have gone unnoticed in single substance risk assessments as individual phthalates levels were below corresponding HBM-GVs. Thus, our results underline the importance of mixture risk assessment approaches to adequately address risks from concurrent chemical exposure. © 2022 Published by Elsevier GmbH.en
dc.format.extent1 Onlineresource (13 Pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-2108
dc.identifier.urihttps://openumwelt.de/handle/123456789/2555
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.titleCumulative risk assessment of five phthalates in European children and adolescents
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2022.114052
local.bibliographicCitation.volume246 (2022)
local.collectionAufsätze
local.contributor.authorId(DE-588)184568781
local.contributor.authorId02188720
local.identifier.catalogId02494256
local.ingest.leader05896naa a2200000uu 4500
local.jointTitleCUMULATIVE RISK ASSESSMENT OF FIVE PHTHALATES IN EUROPEAN CHILDREN AND ADOLESCENTS
local.reviewtrue
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local.source.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
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