Publikation:
Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma

Kurzanzeige
dc.contributor.authorEngel, Kathrin M.
dc.contributor.authorBaumann, Sven
dc.contributor.authorRolle-Kampczyk, Ulrike
dc.date.accessioned2024-06-16T14:22:19Z
dc.date.available2024-06-16T14:22:19Z
dc.date.issued2019
dc.description.abstractIn 50% of all infertility cases, the male is subfertile or infertile, however, the underlying mechanisms are often unknown. Even when assisted reproductive procedures such as in vitro fertilization and intracytoplasmic sperm injection are performed, the causes of male factor infertility frequently remain elusive. Since the overall activity of cells is closely linked to their metabolic capacity, we analyzed a panel of 180 metabolites in human sperm and seminal plasma and elucidated their associations with spermiogram parameters. Therefore, metabolites from a group of 20 healthy donors were investigated using a targeted LC-MS/MS approach. The correlation analyses of the amino acids, biogenic amines, acylcarnitines, lysophosphatidylcholines, phosphatidylcholines, sphingomyelins and sugars from sperm and seminal plasma with standard spermiogram parameters revealed that metabolites in sperm are closely related to sperm motility, whereas those in seminal plasma are closely related to sperm concentration and morphology. This study provides essential insights into the metabolome of human sperm and seminal plasma and its associations with sperm functions. This metabolomics technique could be a promising screening tool to detect the factors of male infertility in cases where the cause of infertility is unclear. Quelle: https://journals.plos.orgen
dc.format.extent1 Onlineressource
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-2096
dc.identifier.urihttps://openumwelt.de/handle/123456789/4561
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleMetabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma
dc.title.alternativeMetabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitlePLoS one
local.bibliographicCitation.originalDOI10.1371/journal.pone.0211679
local.bibliographicCitation.volume(2019)
local.collectionAufsätze
local.contributor.authorId(DE-588)1145281907
local.contributor.authorId02184010
local.contributor.authorId00363860
local.identifier.catalogId02473390
local.ingest.leader04738naa a2200000uu 4500
local.jointTitleMETABOLOMIC PROFILING REVEALS CORRELATIONS BETWEEN SPERMIOGRAM PARAMETERS AND THE METABOLITES PRESENT IN HUMAN SPERMATOZOA AND SEMINAL PLASMA
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublicationda10b8ef-b84e-4cb3-b8c8-f4b5215493bf
relation.isAuthorOfPublication.latestForDiscoveryda10b8ef-b84e-4cb3-b8c8-f4b5215493bf
Dateien
Sammlungen
Aufsätze