Publikation:
The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values for selected phthalates and a substitute plasticizer

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dc.contributor.authorApel, Petra
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorRousselle, Christophe
dc.contributor.authorLange, Rosa
dc.date.accessioned2024-06-16T13:35:25Z
dc.date.available2024-06-16T13:35:25Z
dc.date.issued2021
dc.description.abstractUbiquitous use of plasticizers has led to a widespread internal exposure of the European population. Until today, metabolites are detected in almost every urine sample analysed. This raised the urgent need for a toxicological interpretation of the internal exposure levels. The European Human Biomonitoring Initiative (HBM4EU) contributes substantially to the knowledge on the actual exposure of European citizens to chemicals prioritised within HBM4EU, on their potential impact on health and on the interpretation of these data to improve policy making. On that account, human biomonitoring guidance values (HBM-GVs) are derived for the general population and the occupationally exposed population agreed at HBM4EU consortium level. These values can be used to assess phthalate exposure levels measured in HBM studies in a health risk assessment context. HBM-GVs were derived for five phthalates (DEHP, DnBP, DiBP, BBzP and DPHP) and for the non-phthalate substitute Hexamoll® DINCH. For the adult general population, the HBM-GVs for the specific metabolite(s) of the respective parent compounds in urine are the following: 0.5 mg/L for the sum of 5-oxo-MEHP and 5-OH-MEHP; 0.19 mg/L for MnBP, 0.23 mg/L for MiBP; 3 mg/L for MBzP; 0.5 mg/L for the sum of oxo-MPHP and OH-MPHP and 4.5 mg/L for the sum of OH-MINCH and cx-MINCH. The present paper further specifies HBM-GVs for children and for workers. Quelle: © 2021 The Author(s)en
dc.format.extent1 Onlineressource (8 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-2008
dc.identifier.urihttps://openumwelt.de/handle/123456789/3333
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBürgerinitiative
dc.subjectDINCH
dc.subjectEuropapolitik
dc.subjectExposition
dc.subjectHuman-Biomonitoring
dc.subjectPhthalsäureester
dc.subjectStoffwechselprodukt
dc.subjectUbiquität
dc.subjectWertermittlung
dc.titleThe European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values for selected phthalates and a substitute plasticizer
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2021.113722
local.bibliographicCitation.volume234 (2021)
local.collectionAufsätze
local.contributor.authorId(DE-588)184568781
local.contributor.authorId(DE-588)18159966X
local.contributor.authorId02188290
local.identifier.catalogId02485799
local.ingest.leader06467naa a2200000uu 4500
local.jointTitleTHE EUROPEAN HUMAN BIOMONITORING INITIATIVE HBM4EU HUMAN BIOMONITORING GUIDANCE VALUES FOR SELECTED PHTHALATES AND A SUBSTITUTE PLASTICIZER
local.reviewtrue
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