Publikation:
Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

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dc.contributor.authorSchillemans, Tessa
dc.contributor.authorIszatt, Nina
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorRemy, Sylvie
dc.contributor.authorVogel, Nina
dc.date.accessioned2024-06-16T13:07:59Z
dc.date.available2024-06-16T13:07:59Z
dc.date.issued2023
dc.description.abstractPer- and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU) initiative. We used data from 1957 teenagers (12-18 yrs) that were part of the HBM4EU aligned studies, consisting of nine HBM studies (NEBII, Norway; Riksmaten Adolescents 2016-17, Sweden; PCB cohort (follow-up), Slovakia; SLO CRP, Slovenia; CROME, Greece; BEA, Spain; ESTEBAN, France; FLEHS IV, Belgium; GerES V-sub, Germany). Twelve PFAS were measured in blood, whilst weight and height were measured by field nurse/physician or self-reported in questionnaires. We assessed associations between PFAS and age- and sex-adjusted BMI z-scores using linear and logistic regression adjusted for potential confounders. Random-effects meta-analysis and mixed effects models were used to pool studies. We assessed mixture effects using molar sums of exposure biomarkers with toxicological/structural similarities and quantile g-computation. In all studies, the highest concentrations of PFAS were PFOS (medians ranging from 1.34 to 2.79 mikro/L). There was a tendency for negative associations with BMI z-scores for all PFAS (except for PFHxS and PFHpS), which was borderline significant for the molar sum of [PFOA and PFNA] and significant for single PFOA [beta-coefficient (95% CI) per interquartile range fold change = -0.06 (-0.17, 0.00) and -0.08 (-0.15, -0.01), respectively]. Mixture assessment indicated similar negative associations of the total mixture of [PFOA, PFNA, PFHxS and PFOS] with BMI z-score, but not all compounds showed associations in the same direction: whilst [PFOA, PFNA and PFOS] were negatively associated, [PFHxS] associated positively with BMI z-score. Our results indicated a tendency for associations of relatively low PFAS concentrations with lower BMI in European teenagers. More prospective research is needed to investigate this potential relationship and its implications for health later in life. © 2022 The Authorsen
dc.format.extent1 Onlineressource (11 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1970
dc.identifier.urihttps://openumwelt.de/handle/123456789/2468
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiomonitoring
dc.subjectExposition
dc.subjectPerfluoroctansulfonsäure
dc.subjectPerfluoroktansäure
dc.subjectPolychlorierte Biphenyle
dc.subjectBundesrepublik Deutschland
dc.subjectEuropa
dc.titleCross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Pollution
local.bibliographicCitation.originalDOI10.1016/j.envpol.2022.120566
local.bibliographicCitation.volume316/1 (2023), Heft 120566
local.collectionAufsätze
local.contributor.authorId02191182
local.contributor.authorId02191183
local.contributor.authorId02190360
local.identifier.catalogId02495256
local.ingest.leader07240naa a2200000uu 4500
local.jointTitleCROSSSECTIONAL ASSOCIATIONS BETWEEN EXPOSURE TO PER AND POLYFLUOROALKYL SUBSTANCES AND BODY MASS INDEX AMONG EUROPEAN TEENAGERS IN THE HBM4EU ALIGNED STUDIES
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/
local.staffPublicationtrue
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relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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