Publikation:
Glyphosate and AMPA in human urine of HBM4EU-aligned studies: Part B adults

Kurzanzeige
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorRemy, Sylvie
dc.contributor.authorBessems, Jos
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T13:10:50Z
dc.date.available2024-06-16T13:10:50Z
dc.date.issued2022
dc.description.abstractWithin HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019-2020); ESTEBAN France (2014-2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05-0.1 (micro)g/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 (mirco)g/L urine for Gly and between 0.21 and 0.38 (mirco)g/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. © 2022 by the authorsen
dc.format.extent1 Onlineresource (11 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1866
dc.identifier.urihttps://openumwelt.de/handle/123456789/2627
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectGlyphosat
dc.subjectExposition
dc.titleGlyphosate and AMPA in human urine of HBM4EU-aligned studies: Part B adults
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10100552
local.bibliographicCitation.volume10 (2022), Heft 10
local.collectionAufsätze
local.contributor.authorId02157105
local.contributor.authorId02190360
local.contributor.authorId02182516
local.identifier.catalogId02492835
local.ingest.leader05653naa a2200000uu 4500
local.jointTitleGLYPHOSATE AND AMPA IN HUMAN URINE OF HBM4EUALIGNED STUDIES PART B ADULTS
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
Dateien
Sammlungen
Aufsätze