Publikation:
Screening the baseline fish bioconcentration factor of various types of surfactants using phospholipid binding data

Kurzanzeige
dc.contributor.authorDroge, Steven T. J.
dc.contributor.authorScherpenisse, Peter
dc.contributor.authorArnot, Jon A.
dc.contributor.authorvon der Ohe, Peter C.
dc.date.accessioned2024-06-16T13:30:40Z
dc.date.available2024-06-16T13:30:40Z
dc.date.issued2021
dc.description.abstractFish bioconcentration factors (BCFs) are commonly used in chemical hazard and risk assessment. For neutral organic chemicals BCFs are positively correlated with the octanol-water partition ratio (KOW), but KOW is not a reliable parameter for surfactants. Membrane lipid-water distribution ratios (DMLW) can be accurately measured for all kinds of surfactants, using phospholipid-based sorbents. This study first demonstrates that DMLW values for ionic surfactants are more than 100â€č000 times higher than the partition ratio to fish-oil, representing neutral storage lipid. A non-ionic alcohol ethoxylate surfactant showed almost equal affinity for both lipid types. Accordingly, a baseline screening BCF value for surfactants (BCFbaseline) can be approximated for ionic surfactants by multiplying DMLW by the phospholipid fraction in tissue, and for non-ionic surfactants by multiplying DMLW by the total lipid fraction. We measured DMLW values for surfactant structures, including linear and branched alkylbenzenesulfonates, an alkylsulfoacetate and an alkylethersulfate, bis(2-ethylhexyl)-surfactants (e.g., docusate), zwitterionic alkylbetaines and alkylamine-oxides, and a polyprotic diamine. Together with sixty previously published DMLW values for surfactants, structure-activity relationships were derived to elucidate the influence of surfactant specific molecular features on DMLW. For 23 surfactant types, we established the alkyl chain length at which BCFbaseline would exceed the EU REACH bioaccumulation (B) threshold of 2000 L kg-1, and would therefore require higher tier assessments to further refine the BCF estimate. Finally, the derived BCFbaseline are compared with measured literature in vivo BCF data where available, suggesting that refinements, most notably reliable estimates of biotransformation rates, are needed for most surfactant types. © Royal Society of Chemistry 2021en
dc.format.extent1 Onlineressource (pages 1930-1948)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1851
dc.identifier.urihttps://openumwelt.de/handle/123456789/3158
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleScreening the baseline fish bioconcentration factor of various types of surfactants using phospholipid binding data
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental science: processes & impacts
local.bibliographicCitation.originalDOI10.1039/d1em00327e
local.bibliographicCitation.volume23 (2021), Heft 12
local.collectionAufsätze
local.contributor.authorId02188792
local.contributor.authorId02188793
local.contributor.authorId02132710
local.identifier.catalogId02487294
local.ingest.leader05114naa a2200000uu 4500
local.jointTitleSCREENING THE BASELINE FISH BIOCONCENTRATION FACTOR OF VARIOUS TYPES OF SURFACTANTS USING PHOSPHOLIPID BINDING DATA
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublication8a15863c-b442-48fb-ae42-6f18436acb85
relation.isAuthorOfPublication.latestForDiscovery8a15863c-b442-48fb-ae42-6f18436acb85
Dateien
Sammlungen
Aufsätze