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Sensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry

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dc.contributor.authorConnolly, Alison
dc.contributor.authorKoslitz, Stephan
dc.contributor.authorBury, Daniel
dc.contributor.authorConrad, André
dc.contributor.authorKolossa-Gehring, Marike
dc.date.accessioned2024-06-16T14:04:52Z
dc.date.available2024-06-16T14:04:52Z
dc.date.issued2020
dc.description.abstractGlyphosate is the highest volume herbicide used worldwide, and its main biodegradation product is aminomethylphosphonic acid (AMPA), both are listed as priority substances in the Human Biomonitoring for Europe (HBM4EU) initiative which aims at improving policy by filling knowledge gaps by targeted research. The objective of the current study was to advance the sensitivity of an existing gas chromatography-tandem mass spectrometry analytical method to measure environmental population exposures. A 50% lower limit of quantification of 0.05 (my)g/L was achieved for both analytes by slight modifications in sample work-up, and use of another isotope labelled internal standard. In a pilot study, 41 urine samples from the general German population were analysed, of which glyphosate and AMPA could be quantified in 66% and 90% of the samples respectively, which is sufficient to reliably describe distributions of urinary concentrations in the non-occupationally exposed population. © 2020 The Authorsen
dc.format.extent1 Onlineresource (5 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1845
dc.identifier.urihttps://openumwelt.de/handle/123456789/4173
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectGlyphosat
dc.subjectHarn
dc.subjectHuman-Biomonitoring
dc.titleSensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry
dc.title.alternativeSensitive and selective quantification of glyphosate and aminomethylphosphonic acid (AMPA) in urine of the general population by gas chromatography-tandem mass spectrometry
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences
local.bibliographicCitation.originalDOI10.1016/j.jchromb.2020.122348
local.bibliographicCitation.volume1158 (2020)
local.collectionAufsätze
local.contributor.authorId02182918
local.contributor.authorId02158912
local.contributor.authorId02172065
local.identifier.catalogId02477061
local.ingest.leader05927naa a2200000uu 4500
local.jointTitleSENSITIVE AND SELECTIVE QUANTIFICATION OF GLYPHOSATE AND AMINOMETHYLPHOSPHONIC ACID AMPA IN URINE OF THE GENERAL POPULATION BY GAS CHROMATOGRAPHYTANDEM MASS SPECTROMETRY
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