Publikation:
Cylindrospermopsin toxicity in mice following a 90-d oral exposure

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dc.contributor.authorChernoff, Neil
dc.contributor.authorHill, D.J.
dc.contributor.authorChorus, Ingrid
dc.date.accessioned2024-06-16T14:52:13Z
dc.date.available2024-06-16T14:52:13Z
dc.date.issued2018
dc.description.abstractCylindrospermopsin (CYN) is a toxin associated with numerous species of freshwater cyanobacteria throughout the world. It is postulated to have caused an episode of serious illnesses in Australia through treated drinking water, as well as lethal effects in livestock exposed to water from farm ponds. Toxicity included effects indicative of both hepatic and renal dysfunction. In humans, symptoms progressed from initial hepatomegaly, vomiting, and malaise to acidosis and hypokalemia, bloody diarrhea, and hyperemia in mucous membranes. Laboratory animal studies predominantly involved the intraperitoneal (i.p.) route of administration and confirmed this pattern of toxicity with changes in liver enzyme activities and histopathology consistent with hepatic injury and adverse renal effects. The aim of this study was designed to assess subchronic oral exposure (90 d) of purified CYN from 75 to 300 Ìg/kg/d in mouse. At the end of the dosing period, examinations of animals noted (1) elevated organ to body weight ratios of liver and kidney at all dose levels, (2) treatment-related increases in serum alanine aminotransferase (ALT) activity, (3) decreased blood urea nitrogen (BUN) and cholesterol concentrations in males, and (4) elevated monocyte counts in both genders. Histopathological alterations included hepatocellular hypertrophy and cord disruption in the liver, as well as renal cellular hypertrophy, tubule dilation, and cortical tubule lesions that were more prominent in males. A series of genes were differentially expressed including Bax (apoptosis), Rpl6 (tissue regeneration), Fabp4 (fatty acid metabolism), and Proc (blood coagulation). Males were more sensitive to many renal end points suggestive of toxicity. At the end of exposure, toxicity was noted at all dose levels, and the 75 Ìg/kg group exhibited significant effects in liver and kidney/body weight ratios, reduced BUN, increased serum monocytes, and multiple signs of histopathology indicating that a no-observed-adverse-effect level could not be determined for any dose level. Quelle: https://www.tandfonline.comen
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1843
dc.identifier.urihttps://openumwelt.de/handle/123456789/5508
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleCylindrospermopsin toxicity in mice following a 90-d oral exposure
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleJournal of Toxicology and Environmental Health
local.bibliographicCitation.originalDOI10.1080/15287394.2018.1460787
local.bibliographicCitation.volume81 (2018), Heft 13, 1 Onlineressource (Pages 549-566)
local.collectionAufsätze
local.contributor.authorId00259902
local.contributor.authorId00040185
local.identifier.catalogId02464348
local.ingest.leader05323naa a2200000uu 4500
local.jointTitleCYLINDROSPERMOPSIN TOXICITY IN MICE FOLLOWING A 90D ORAL EXPOSURE
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublication8332d730-8fa3-45be-9068-9d8d61f864f6
relation.isAuthorOfPublication.latestForDiscovery8332d730-8fa3-45be-9068-9d8d61f864f6
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