Publikation:
Time trends of acrylamide exposure in Europe: combined analysis of published reports and current HBM4EU Studies

Kurzanzeige
dc.contributor.authorPoteser, Michael
dc.contributor.authorHahn, Domenica
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorSchettgen, Thomas
dc.contributor.authorVogel, Nina
dc.contributor.authorWeber, Till
dc.contributor.authorZimmermann, Philipp
dc.date.accessioned2024-06-16T13:10:51Z
dc.date.available2024-06-16T13:10:51Z
dc.date.issued2022
dc.description.abstractMore than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children. © 2022 by the authorsen
dc.format.extent1 Onlineresource (24 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1797
dc.identifier.urihttps://openumwelt.de/handle/123456789/2630
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectAcrylamid
dc.subjectBeurteilungspegel
dc.subjectHuman-Biomonitoring
dc.titleTime trends of acrylamide exposure in Europe: combined analysis of published reports and current HBM4EU Studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10080481
local.bibliographicCitation.volume10 (2022), Heft 8
local.collectionAufsätze
local.contributor.authorId02190211
local.contributor.authorId02190355
local.contributor.authorId02082994
local.identifier.catalogId02492831
local.ingest.leader06751naa a2200000uu 4500
local.jointTitleTIME TRENDS OF ACRYLAMIDE EXPOSURE IN EUROPE COMBINED ANALYSIS OF PUBLISHED REPORTS AND CURRENT HBM4EU STUDIES
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
relation.isAuthorOfPublication6d9d078e-fe57-4a02-b4fe-dc331e19d4e3
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublicationb5969380-709f-49f3-9d11-d6293091c343
relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication510e28df-589c-48df-a9af-0cc29caca61f
relation.isAuthorOfPublication.latestForDiscovery6d9d078e-fe57-4a02-b4fe-dc331e19d4e3
Dateien
Sammlungen
Aufsätze