Publikation:
A tiered approach for assessing individual and combined risk of pyrethroids using Human Biomonitoring Data

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dc.contributor.authorTarazona, Jose V.
dc.contributor.authorApel, Petra
dc.contributor.authorCattaneo, Irene
dc.contributor.authorNiemann, Lars
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T13:10:53Z
dc.date.available2024-06-16T13:10:53Z
dc.date.issued2022
dc.description.abstractPyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014-2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1-0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future. © 2022 by the authorsen
dc.format.extent1 Onlineresource (22 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1771
dc.identifier.urihttps://openumwelt.de/handle/123456789/2633
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectPyrethroid
dc.subjectPrüfwert
dc.titleA tiered approach for assessing individual and combined risk of pyrethroids using Human Biomonitoring Data
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10080451
local.bibliographicCitation.volume10 (2022), Heft 8
local.collectionAufsätze
local.contributor.authorId00311895
local.contributor.authorId02190357
local.contributor.authorId00359304
local.identifier.catalogId02492828
local.ingest.leader06107naa a2200000uu 4500
local.jointTitleA TIERED APPROACH FOR ASSESSING INDIVIDUAL AND COMBINED RISK OF PYRETHROIDS USING HUMAN BIOMONITORING DATA
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
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relation.isAuthorOfPublication.latestForDiscovery28f9b1e3-5211-44ba-8d52-c462cd5fe32d
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