Publikation:
A novel GC-MS method for the determination and quantification of metformin in surface water

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dc.contributor.authorGoedecke, Caroline
dc.contributor.authorFettig, Ina
dc.contributor.authorPiechotta, C.
dc.date.accessioned2024-06-16T15:36:57Z
dc.date.available2024-06-16T15:36:57Z
dc.date.issued2017
dc.description.abstractDrug therapy for diabetes mellitus has increased significantly in recent years. 1,1-Dimethylbiguanide hydrochloride (metformin) is the most common drug used for the treatment of diabetes. Metformin is not metabolized in the human body and enters the water cycle via sewage. A new gas chromatography-mass spectrometry (GC-MS) method has been developed which enables the quantification of metformin in surface water samples even at low concentrations in the ng L-1 range. A solid phase extraction (SPE) method for the preconcentration of metformin and the internal standard 1-butylbiguanide (buformin) was established, and the method parameters such as the composition and volume of the eluent were optimized. Derivatization of metformin and buformin was obtained by using n-methyl-bis (trifluoroacetamide) (MBTFA). The reaction conditions of the derivatization, such as the reaction temperature and volume of the derivatization agent, were evaluated. The limit of detection (LOD) and limit of quantification (LOQ) were determined to be 3.9 ng L-1 and 12 ng L-1 in surface water samples. Linearity was shown over a concentration range of 10-50 ng L-1. The good performance of the method was demonstrated by comparison with a liquid chromatography tandem mass spectrometry (LC-MS/MS) method. The results indicate that the GC-MS method is a reliable and sensitive alternative for the quantification of metformin in surface water. Quelle: http://pubs.rsc.orgen
dc.format.extent1 Onlineressource (Seite 1580-1584)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1737
dc.identifier.urihttps://openumwelt.de/handle/123456789/6948
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleA novel GC-MS method for the determination and quantification of metformin in surface water
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleAnalytical methods
local.bibliographicCitation.originalDOI10.1039/C6AY02606K
local.bibliographicCitation.volume9 (2017), Heft 10
local.collectionAufsätze
local.contributor.authorId02176195
local.contributor.authorId02176196
local.identifier.catalogId02443599
local.ingest.leader04711naa a2200000uu 4500
local.jointTitleA NOVEL GCMS METHOD FOR THE DETERMINATION AND QUANTIFICATION OF METFORMIN IN SURFACE WATER
local.sourcecatalog
local.source.urihttp://pubs.rsc.org/en/content/articlelanding/2017/ay/c6ay02606k#!divAbstract
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