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Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems

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dc.contributor.authorBerkner, Silvia
dc.contributor.authorThierbach, Claudia
dc.date.accessioned2024-06-16T16:36:00Z
dc.date.available2024-06-16T16:36:00Z
dc.date.issued2013
dc.description.abstractHuman pharmaceutical active ingredients that are orally or parenterally administered may be metabolised in the body and after excretion may be further transformed in the receiving environmental compartments. The optimal outcome from an environmental point of view-complete mineralisation-is rarely observed. Small molecule pharmaceuticals are commonly not readily biodegradable according to Organisation for Economic Cooperation and Development (OECD) 301 tests. However, primary transformation is often observed. To gain information on the transformation of active ingredients in the environment, long-term studies like transformation in aquatic water/sediment systems according to OECD guideline 308 are required for the environmental risk assessment for human active pharmaceutical ingredients. Studies received until mid 2010 as part of the dossiers for marketing authorisation applications were evaluated concerning transformation products. The evaluation revealed that in 70 % of the studies, at least one transformation product (TP) is formed above 10 % of the originally applied dose, but in only 26 % of the studies are all TP identified. The evaluation also revealed that some TP of pharmaceutical active ingredients show a considerably longer DT50 compared to the parent compound. An example is the TP (val)sartan acid that is formed from an antihypertensive compound.<BR>Quelle: http://link.springer.comen
dc.format.extent7 Seiten
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1672
dc.identifier.urihttps://openumwelt.de/handle/123456789/9202
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiologischer Abbau
dc.subjectBelebtschlamm
dc.titleBiodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems
dc.typeWissenschaftlicher Artikel
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Science and Pollution Research
local.bibliographicCitation.originalDOI10.1007/s11356-013-1868-6
local.bibliographicCitation.volume(2013), [online article]
local.collectionAufsätze
local.contributor.authorId02143078
local.identifier.catalogId02393183
local.ingest.leader04493naa a2200000uu 4500
local.jointTitleBIODEGRADABILITY AND TRANSFORMATION OF HUMAN PHARMACEUTICAL ACTIVE INGREDIENTS IN ENVIRONMENTALLY RELEVANT TEST SYSTEMS
local.sourcecatalog
local.source.urihttp://link.springer.com/content/pdf/10.1007%2Fs11356-013-1868-6.pdf
local.staffPublicationtrue
relation.isAuthorOfPublicationa8086cbf-5d99-4f78-92ef-a3b44ad81db2
relation.isAuthorOfPublication.latestForDiscoverya8086cbf-5d99-4f78-92ef-a3b44ad81db2
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