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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2016
The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
Herausgeber
Quelle
The Lancet
(2016)
(2016)
Schlagwörter
Zitation
STANAWAY, Jeffrey, Abraham D. FLAXMAN, Mohsen NAGHAVI, Christina FITZMAURICE, Theo VOS, Ibrahim ABUBAKAR, Laith J. ABU-RADDAD, Reza ASSADI, Neeraj BHALA, Benjamin COWIE, Mohammad H. FOROUZANFOUR, Justina GROEGER, Khayriyyah MOHD HANAFIAH, Kathryn H. JACOBSEN, Spencer L. JAMES, Jennifer MACLACHLAN, Reza MALEKZADEH, Natasha K. MARTIN, Ali A. MOKDAD, Ali H. MOKDAD, Christopher J. L. MURRAY, Dietrich PLASS, Saleem RANA, David B. REIN, Jan Hendrik RICHARDUS, Juan SANABRIA, Mete SAYLAN, Saeid SHARAZ, Samuel SO, Vasiliy V. VLASSOV, Elisabete WEIDERPASS, Steven t. WIERSMA, Mustafa YOUNIS, Chuanhua YU, Maysaa EL SAYED ZAKI und Graham S. COOKE, 2016. The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013. The Lancet [online]. 2016. Bd. (2016). DOI 10.60810/openumwelt-1579. Verfügbar unter: https://openumwelt.de/handle/123456789/7509
Zusammenfassung englisch
Background
With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013.
Methods
We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the proportion of cirrhosis and liver cancer attributable to each cause. We then estimated cause-specific prevalence as the product of the total prevalence and the proportion attributable to a specific cause. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs).
Findings
Between 1990 and 2013, global viral hepatitis deaths increased from 0ı89 million (95% uncertainty interval [UI] 0ı86-0ı94) to 1ı45 million (1ı38-1ı54); YLLs from 31ı0 million (29ı6-32ı6) to 41ı6 million (39ı1-44ı7); YLDs from 0ı65 million (0ı45-0ı89) to 0ı87 million (0ı61-1ı18); and DALYs from 31ı7 million (30ı2-33ı3) to 42ı5 million (39ı9-45ı6). In 2013, viral hepatitis was the seventh (95% UI seventh to eighth) leading cause of death worldwide, compared with tenth (tenth to 12th) in 1990.
Interpretation
Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, the absolute burden and relative rank of viral hepatitis increased between 1990 and 2013. The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
Quelle: http://www.sciencedirect.com
With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013.
Methods
We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the proportion of cirrhosis and liver cancer attributable to each cause. We then estimated cause-specific prevalence as the product of the total prevalence and the proportion attributable to a specific cause. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs).
Findings
Between 1990 and 2013, global viral hepatitis deaths increased from 0ı89 million (95% uncertainty interval [UI] 0ı86-0ı94) to 1ı45 million (1ı38-1ı54); YLLs from 31ı0 million (29ı6-32ı6) to 41ı6 million (39ı1-44ı7); YLDs from 0ı65 million (0ı45-0ı89) to 0ı87 million (0ı61-1ı18); and DALYs from 31ı7 million (30ı2-33ı3) to 42ı5 million (39ı9-45ı6). In 2013, viral hepatitis was the seventh (95% UI seventh to eighth) leading cause of death worldwide, compared with tenth (tenth to 12th) in 1990.
Interpretation
Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, the absolute burden and relative rank of viral hepatitis increased between 1990 and 2013. The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
Quelle: http://www.sciencedirect.com