Publikation:
Cellular uptake and toxicological effects of differently sized zinc oxide nanoparticles in intestinal cells

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dc.contributor.authorMittag, Anna
dc.contributor.authorHöra, Christian
dc.contributor.authorKämpfe, Alexander David
dc.contributor.authorKuckelkorn, Jochen
dc.date.accessioned2024-06-16T13:29:53Z
dc.date.available2024-06-16T13:29:53Z
dc.date.issued2021
dc.description.abstractDue to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Consequently, the aim of our study was to investigate the cellular uptake of two differently sized ZnO NP (<50 nm and <100 nm; 12-1229 (micro)mol/L) using two human intestinal cell lines (Caco-2 and LT97) and to examine the possible resulting toxic effects. ZnO NP (<50 nm and <100 nm) were internalized by both cell lines and led to intracellular changes. Both ZnO NP caused time- and dose-dependent cytotoxic effects, especially at concentrations of 614 (micro)mol/L and 1229 (micro)mol/L, which was associated with an increased rate of apoptotic and dead cells. ZnO NP < 100 nm altered the cell cycle of LT97 cells but not that of Caco-2 cells. ZnO NP < 50 nm led to the formation of micronuclei in LT97 cells. The Ames test revealed no mutagenicity for both ZnO NP. Our results indicate the potential toxicity of ZnO NP after oral exposure, which should be considered before application. © 2021 by the authorsen
dc.format.extent1 Onliuneresource (24 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1574
dc.identifier.urihttps://openumwelt.de/handle/123456789/3084
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectZellzyklus
dc.subjectZytotoxizität
dc.subjectGenotoxizität
dc.subjectZinkoxid
dc.titleCellular uptake and toxicological effects of differently sized zinc oxide nanoparticles in intestinal cells
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics9050096
local.bibliographicCitation.volume9 (2021), Heft 5
local.collectionAufsätze
local.contributor.authorId02188920
local.contributor.authorId(DE-588)1232455679
local.contributor.authorId(DE-588)112014471X
local.identifier.catalogId02487676
local.ingest.leader05565naa a2200000uu 4500
local.jointTitleCELLULAR UPTAKE AND TOXICOLOGICAL EFFECTS OF DIFFERENTLY SIZED ZINC OXIDE NANOPARTICLES IN INTESTINAL CELLS
local.reviewtrue
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