Publikation:
Increasing exposure to the UV filters octocrylene and 2-ethylhexyl salicylate in Germany from 1996 to 2020: Human biomonitoring in 24-h urine samples of the German Environmental Specimen Bank (ESB)

Kurzanzeige
dc.contributor.authorBury, Daniel
dc.contributor.authorEbert, Katharina E.
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T12:35:54Z
dc.date.available2024-06-16T12:35:54Z
dc.date.issued2023
dc.description.abstractThe UV filters octocrylene (OC) and 2-ethylhexyl salicylate (EHS) are commonly used in sunscreens and frequently detected in environmental media. However, knowledge on human exposures is scarce. In this human biomonitoring (HBM) study, we analyzed concentrations of exposure biomarkers specific to OC (CPAA, DOCCA, 5OH-OC) and EHS (5OH-EHS, 5oxo-EHS, 5cx-EPS) in 24-h urine samples (n=420) from the German Environmental Specimen Bank (ESB). These samples were collected from German students (20-29 years; 30 males/30 females per year) between 1996 and 2020 (4-year intervals; collection in winter). We found continuously increasing OC and EHS exposures (Jonckheere-Terpstra; p < 0.001) documented by very few to no samples with concentrations of the most sensitive biomarkers CPAA and 5cx-EPS above the limit of quantification (LOQ) in 1996 (5 % and 0 %, respectively) and reaching 100 % and 93 % above the LOQ in 2016, with median concentrations of 4.79 and 0.071 (micro)g/L, respectively. In 2020, biomarker concentrations slightly decreased to 3.12 (micro)g/L CPAA (97 %>LOQ) and 0.060 (micro)g/L 5cx-EPS (88 %>LOQ). This general trend was confirmed by the other biomarkers, however at lower detection rates. Based on metabolite excretion in the 24-h urine samples and human toxicokinetic data, we calculated maximum daily intakes (DI) of 17 (micro)g/(kg bw * d) OC and 59 (micro)g/(kg bw * d) EHS. Based on a derived no-effect level (DNEL) of 0.8 mg/(kg bw * d), the OC exposures of individuals in our study did not indicate any health risk. Similarly, for EHS all biomarker concentrations were well below the HBM-I values of 12 (micro)g/L 5OH-EHS and 11 (micro)g/L 5cx-EPS. Our data proves the general applicability of specific OC and EHS metabolites for HBM in the general population and shows clearly increasing exposures. Higher (co-)exposures must be expected in populations with increased sunscreen use such as (summer) vacationers, children and outdoor workers. © 2023 The Author(s).en
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1534
dc.identifier.urihttps://openumwelt.de/handle/123456789/1407
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectExpositionsabschätzung
dc.subjectRisikoanalyse
dc.titleIncreasing exposure to the UV filters octocrylene and 2-ethylhexyl salicylate in Germany from 1996 to 2020: Human biomonitoring in 24-h urine samples of the German Environmental Specimen Bank (ESB)
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironment International
local.bibliographicCitation.originalDOI10.1016/j.envint.2023.108334
local.bibliographicCitation.volume182 (2023)
local.collectionAufsätze
local.contributor.authorId02172065
local.contributor.authorId02193347
local.identifier.catalogId02502328
local.ingest.leader06108naa a2200000uu 4500
local.jointTitleINCREASING EXPOSURE TO THE UV FILTERS OCTOCRYLENE AND 2ETHYLHEXYL SALICYLATE IN GERMANY FROM 1996 TO 2020 HUMAN BIOMONITORING IN 24H URINE SAMPLES OF THE GERMAN ENVIRONMENTAL SPECIMEN BANK ESB
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
Dateien
Sammlungen
Aufsätze