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Alteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line

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dc.contributor.authorSohn, Juhae
dc.contributor.authorKim, Sujin
dc.contributor.authorKho, Younglim
dc.contributor.authorKoschorreck, Jan
dc.contributor.authorChoi, Kyungho
dc.date.accessioned2024-06-16T15:55:03Z
dc.date.available2024-06-16T15:55:03Z
dc.date.issued2016
dc.description.abstractLow molecular weight phthalates, such as diethyl phthalate (DEP), benzyl butyl phthalate (BBzP), or diisobutyl phthalate (DiBP), are suspected to disrupt endocrine system. However, their adverse effects on sex steroid hormones and underlying mechanisms are not well-documented. The aim of this study is to investigate the effects of major low molecular weight phthalates (LMWPs), i.e., DEP, BBzP, and DiBP, and their hydrolytic metabolites, on sex steroid hormone system, employing male zebrafish and/or a human adrenocortical carcinoma (H295R) cell. In male zebrafish, 14-day exposure to DEP, BBzP, or DiBP significantly decreased testosterone (T) concentrations. All test compounds significantly up-regulated cyp19agene expression, and down-regulated starand 3âhsd genes in the male fish. In H295R cell, all test compounds except monoisobutyl phthalate (MiBP) reduced T concentrations and increased E2/T ratio. Gene expression changes in H295R cell, e.g., significant down-regulation of StARgene and up-regulation of CYP19A gene, supported depressed synthesis of sex hormones in the adrenal cell. Our results show that not only DEP, BBzP, and DiBP, but also their hydrolytic metabolites disrupt sex hormone balances through modulating key steroidogenic genes in the human adrenal cells and in zebrafish.Quelle: http://www.sciencedirect.com/en
dc.format.extent1 Onlineressource (Seiten 45-54)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1340
dc.identifier.urihttps://openumwelt.de/handle/123456789/7490
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectFisch
dc.titleAlteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleJournal of Hazardous Materials
local.bibliographicCitation.originalDOI10.1016/j.jhazmat.2016.08.008
local.bibliographicCitation.volume320 (2016)
local.collectionAufsätze
local.contributor.authorId02174439
local.contributor.authorId02174440
local.contributor.authorId02174441
local.contributor.authorId02153355
local.identifier.catalogId02437321
local.ingest.leader04924naa a2200000uu 4500
local.jointTitleALTERATION OF SEX HORMONE LEVELS AND STEROIDOGENIC PATHWAY BY SEVERAL LOW MOLECULAR WEIGHT PHTHALATES AND THEIR METABOLITES IN MALE ZEBRAFISH DANIO RERIO ANDOR HUMAN ADRENAL CELL H295R LINE
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relation.isAuthorOfPublication474bf2a4-71af-4362-ac51-4bff4bf59981
relation.isAuthorOfPublication.latestForDiscovery474bf2a4-71af-4362-ac51-4bff4bf59981
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