Publikation:
Time trend of exposure to dechloranes: Plasma samples of German young adults from the environmental specimen bank collected from 1995 to 2017

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dc.contributor.authorFromme, Hermann
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorAschenbrenner, Bettina
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T14:05:24Z
dc.date.available2024-06-16T14:05:24Z
dc.date.issued2020
dc.description.abstractDechloranes, like Dechlorane Plus® are commonly used flame retardants identified by the EU as substances of very high concern (SVHC) because of their persistence and bioaccumulation potential. To characterize the dechlorane exposure of Germans in the last two decades, 180 archived blood plasma samples of the German Environmental Specimen Bank (students aged 20-29 years) collected at six time points between 1995 and 2017 were analyzed for four dechloranes; namely Dechlorane Plus® (syn- and anti-DDC-CO), dechlorane 602 (DDC-DBF), and dechlorane 603 (DDC-Ant). These were quantified using a GC-MS/MS method. Overall, anti- and syn-DDC-CO were detected in 88% and 98% of the samples, whereas DDC-DBF and DDC-Ant were found in 40% and 37% of the samples, respectively. The median (95th percentile) values were 1.0 ng/g lipid weight (l.w.) (3.0 ng/g l.w.). for anti-DDC-CO, 0.6 ng/g l.w (1.9 ng/g l.w.). for syn-DDC-CO, 0.1 ng/g l.w (0.6 ng/g l.w.). for DDC-DBF, and 0.1 ng/g l.w (0.2 ng/g l.w.). for DDC-Ant. The 95th percentile concentrations of the sum of syn- and anti-DDC-CO decreased from 4.2 ng/g l.w. in 1995, to 2.9 ng/g l.w. in 1999, and subsequently increased to 3.7 ng/g l.w. in 2008, and up to 5.9 ng/g l.w. in 2017. A statistically significant decrease with time was observed for DDC-DBF and DDC-Ant, but not for DDC-CO. Our medians found in blood samples in 2017 are similar to those observed in Germany in 2013/14, but higher compared to values reported in other European countries. Overall, more toxicological and monitoring data is needed to better characterize the potential impact on health. © 2020 Elsevier GmbHen
dc.format.extent1 Onlineressource (6 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1324
dc.identifier.urihttps://openumwelt.de/handle/123456789/4190
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBlutplasma
dc.subjectExposition
dc.subjectHuman-Biomonitoring
dc.subjectUmweltprobenbank
dc.subjectPersistenz
dc.subjectAnreicherung
dc.subjectBesonders besorgniserregende Stoffe
dc.titleTime trend of exposure to dechloranes: Plasma samples of German young adults from the environmental specimen bank collected from 1995 to 2017
dc.title.alternativeTime trend of exposure to dechloranes: Plasma samples of German young adults from the environmental specimen bank collected from 1995 to 2017
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2020.113593
local.bibliographicCitation.volume229 (2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)1184443831
local.contributor.authorId00300967
local.contributor.authorId02184968
local.contributor.authorId02184969
local.identifier.catalogId02476946
local.ingest.leader06690naa a2200000uu 4500
local.jointTitleTIME TREND OF EXPOSURE TO DECHLORANES PLASMA SAMPLES OF GERMAN YOUNG ADULTS FROM THE ENVIRONMENTAL SPECIMEN BANK COLLECTED FROM 1995 TO 2017
local.reviewtrue
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relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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