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Application of the closure principle computational approach test to assess ecotoxicological field studies: comparative analysis using earthworm field test abundance data

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dc.contributor.authorDaniels, Benjamin
dc.contributor.authorRoß-Nickoll, Martina
dc.contributor.authorJänsch, Stephan
dc.contributor.authorPieper, Silvia
dc.date.accessioned2024-06-16T13:37:22Z
dc.date.available2024-06-16T13:37:22Z
dc.date.issued2021
dc.description.abstractField studies to determine the effects of chemicals on earthworm communities are generally conducted according to International Organization for Standardization standard 11268-3 (and later comments). However, statistical test procedures suggested in the guideline are frequently criticized, mainly for 2 reasons: 1) Earthworm abundances are count data and often do not fulfill requirements for multiple t tests (normal distribution and homogeneity of variance), and 2) the resulting toxicity metrics of multiple testing procedures (no/lowest-observed-effect concentrations [NOEC/LOEC]) fail to adequately detect the actual level of effects. Recently, a new method to overcome these shortcomings was presented by the introduction of the closure principle computational approach test (CPCAT). We applied this statistical method to assess chemical effects on abundance in a large dataset of 26 earthworm field studies (with up to 3 test chemical application rates) and an additional extended study with 6 application rates. A comparative analysis was provided considering results of well-established multiple testing approaches (Dunnett's test) with particular consideration of the degree of overdispersion found in these data. It was shown that the CPCAT detects substantially more effects in earthworm field tests as statistically significant than standard t test approaches. This lowered the LOEC/NOEC for many chemical treatments to control comparisons. As a consequence, the statistically detected NOECs/LOECs were often set at lower percentage deviations between control and chemical treatment. This is the first time the performance of the CPCAT has been assessed within a comprehensive analysis of earthworm field study data. Environ Toxicol Chem 2021;40:1750-1760. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. © 2021 The Authorsen
dc.format.extent1 Onlineressource (11 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1304
dc.identifier.urihttps://openumwelt.de/handle/123456789/3405
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectÖkotoxikologie
dc.subjectRegenwurm
dc.titleApplication of the closure principle computational approach test to assess ecotoxicological field studies: comparative analysis using earthworm field test abundance data
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Toxicology and Chemistry
local.bibliographicCitation.originalDOI10.1002/etc.5015
local.bibliographicCitation.volume40 (2021), Heft 6
local.collectionAufsätze
local.contributor.authorId02181720
local.contributor.authorId00375965
local.contributor.authorId02079744
local.identifier.catalogId02484851
local.ingest.leader05656naa a2200000uu 4500
local.jointTitleAPPLICATION OF THE CLOSURE PRINCIPLE COMPUTATIONAL APPROACH TEST TO ASSESS ECOTOXICOLOGICAL FIELD STUDIES COMPARATIVE ANALYSIS USING EARTHWORM FIELD TEST ABUNDANCE DATA
local.reviewtrue
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relation.isAuthorOfPublication5795b091-3277-4c79-942b-7375b8c611c3
relation.isAuthorOfPublication.latestForDiscovery5795b091-3277-4c79-942b-7375b8c611c3
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