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Discovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB)

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dc.contributor.authorGöen, Thomas
dc.contributor.authorLermen, Dominik
dc.contributor.authorHildebrand, Jörg
dc.contributor.authorKolossa-Gehring, Marike
dc.date.accessioned2024-06-16T15:01:22Z
dc.date.available2024-06-16T15:01:22Z
dc.date.issued2018
dc.description.abstractThe German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An standardized annual collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution. The number of participants recruited is approximately 120 students per site and year. Directly after the annual sampling process, the human samples are analyzed for selected environmental chemicals. The time-trends of lead in blood, mercury and pentachlorophenol in 24 h-urine and polychlorinated biphenyls in plasma demonstrated a decrease of exposure during the last two decades by about 40-90 percent. In parallel retrospective studies using cryo-archived samples revealed increasing time trends of emerging chemicals used as substitutes for regulated toxicants. The data demonstrates the great relevance of the ESB for the health related environmental monitoring and shows the importance of human biomonitoring as a tool in information based policy making. © 2018 Elsevier B.V. All rights reserved.en
dc.format.extent1 Onlineressource
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1276
dc.identifier.urihttps://openumwelt.de/handle/123456789/5841
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectBiobank
dc.subjectUmweltprobenbank
dc.titleDiscovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB)
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxicology Letters
local.bibliographicCitation.originalDOI10.1016/j.toxlet.2018.06.007
local.bibliographicCitation.volume298 (2018), Seite 194-200
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local.contributor.authorId(DE-588)1036727084
local.contributor.authorId00341773
local.contributor.authorId(DE-588)140763155
local.contributor.authorId02158927
local.contributor.authorId02181277
local.identifier.catalogId02462132
local.ingest.leader05450naa a2200000uu 4500
local.jointTitleDISCOVERING TIMETRENDS OF THE GERMAN POPULATIONS EXPOSURE TO CONTAMINANTS BY ANALYSIS OF HUMAN SAMPLES OF THE GERMAN ENVIRONMENTAL SPECIMEN BANK ESB
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