Publikation:
Advancing human health risk assessment

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dc.contributor.authorLanzoni, Anna
dc.contributor.authorCastoldi, Anna F.
dc.contributor.authorKass, George EN
dc.contributor.authorKolossa-Gehring, Marike
dc.date.accessioned2024-06-16T14:34:54Z
dc.date.available2024-06-16T14:34:54Z
dc.date.issued2019
dc.description.abstractThe current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re-engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break-out session 'Advancing risk assessment science - Human health' at EFSA's third Scientific Conference 'Science, Food and Society' (Parma, Italy, 18ââą Ì21 September 2018). © 2019 European Food Safety Authorityen
dc.format.extent1 Onlineressource (21 Seiten )
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1240
dc.identifier.urihttps://openumwelt.de/handle/123456789/5061
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectExposition
dc.subjectEpidemiologie
dc.subjectLebensmittelhygiene
dc.subjectRisikoanalyse
dc.titleAdvancing human health risk assessment
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEFSA Journal
local.bibliographicCitation.originalDOI10.2903/j.efsa.2019.e170712
local.bibliographicCitation.volume17 (2019), Heft S1
local.collectionAufsätze
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local.contributor.authorId00269657
local.contributor.authorId02182921
local.identifier.catalogId02469084
local.ingest.leader05579naa a2200000uu 4500
local.jointTitleADVANCING HUMAN HEALTH RISK ASSESSMENT
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