Publikation:
Benefits of cooperation among large-scale cohort studies and human biomonitoring projects in environmental health research: An exercise in blood lead analysis of the Environment and Child Health International Birth Cohort Group

Kurzanzeige
dc.contributor.authorNakayama, Shoji F.
dc.contributor.authorConrad, André
dc.contributor.authorEspina, Carolina
dc.contributor.authorKamijima, Michihiro
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.date.accessioned2024-06-16T14:39:17Z
dc.date.available2024-06-16T14:39:17Z
dc.date.issued2019
dc.description.abstractA number of prospective cohort studies are ongoing worldwide to investigate the impact of foetal and neonatal exposures to chemical substances on child health. To assess multiple exposure (mixture) effects and low prevalence health outcomes it is useful to pool data from several studies and conduct mega-data-analysis. To discuss a path towards data harmonization, representatives from several large-scale birth cohort studies and a biomonitoring programme formed a collaborative group, the Environment and Child Health International Birth Cohort Group (ECHIBCG). In this study, an intra-laboratory trial was performed to harmonize existing blood lead measurements within the groups' studies. Then, decentralized analyses were conducted in individual countries' laboratories to evaluate blood lead levels (BLL) in each study. The measurements of pooled BLL samples in French, German and three Japanese laboratories resulted in an overall mean blood lead concentration of 8.66 ng¯1 (95% confidence interval: 8.59-8.72 ng¯1) with 3.0% relative standard deviation. Except for China's samples, BLL from each study were comparable with mean concentrations below or close to 10ng¯1. The decentralized multivariate analyses revealed that all models had coefficients of determination below 0.1. Determinants of BLL were current smoking, age >35 years and overweight or obese status. The three variables were associated with an increase in BLL in each of the five studies, most strongly in France by almost 80% and the weakest effect being in Norway with only 15%; for Japan, with the far largest sample (~18,000), the difference was 36%. This study successfully demonstrated that the laboratory analytical methods were sufficiently similar to allow direct comparison of data and showed that it is possible to harmonize the epidemiological data for joint analysis. This exercise showed the challenges in decentralized data analyses and reinforces the need for data harmonization among studies. © 2019 The Authors. Published by Elsevier GmbH.en
dc.format.extent1 Onlineressource (9 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1131
dc.identifier.urihttps://openumwelt.de/handle/123456789/5163
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectBlei
dc.subjectGravidität
dc.subjectKind
dc.subjectUmwelt
dc.titleBenefits of cooperation among large-scale cohort studies and human biomonitoring projects in environmental health research: An exercise in blood lead analysis of the Environment and Child Health International Birth Cohort Group
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2019.07.005
local.bibliographicCitation.volume(2019)
local.collectionAufsätze
local.contributor.authorId(DE-588)1137684410
local.contributor.authorId02165873
local.contributor.authorId(DE-588)1121761674
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local.contributor.authorId(DE-588)1084188597
local.identifier.catalogId02467783
local.ingest.leader07078naa a2200000uu 4500
local.jointTitleBENEFITS OF COOPERATION AMONG LARGESCALE COHORT STUDIES AND HUMAN BIOMONITORING PROJECTS IN ENVIRONMENTAL HEALTH RESEARCH AN EXERCISE IN BLOOD LEAD ANALYSIS OF THE ENVIRONMENT AND CHILD HEALTH INTERNATIONAL BIRTH COHORT GROUP
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