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PFAS and Phthalate/DINCH exposure in association with age at menarche in teenagers of the HBM4EU aligned studies

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dc.contributor.authorCox, Bianca
dc.contributor.authorWauters, Natasha
dc.contributor.authorRodríguez-Carrillo, Andrea
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorGerofke, Antje
dc.date.accessioned2024-06-16T12:41:57Z
dc.date.available2024-06-16T12:41:57Z
dc.date.issued2023
dc.description.abstractEarly puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases and hormone-dependent cancers. The decrease in age at menarche observed during the past decades has been linked to an increased exposure to endocrine-disrupting compounds (EDCs). Evidence for the association between PFAS and phthalate exposure and menarche onset, however, is inconsistent. We studied the association between PFAS and phthalate/DINCH exposure and age at menarche using data of 514 teenagers (12 to 18 years) from four aligned studies of the Human Biomonitoring for Europe initiative (HBM4EU): Riksmaten Adolescents 2016-2017 (Sweden), PCB cohort (follow-up; Slovakia), GerES V-sub (Germany), and FLEHS IV (Belgium). PFAS concentrations were measured in blood, and phthalate/DINCH concentrations in urine. We assessed the role of each individual pollutant within the context of the others, by using different multi-pollutant approaches, adjusting for age, age- and sex-standardized body mass index z-score and household educational level. Exposure to di(2-ethylhexyl) phthalate (DEHP), especially mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), was associated with an earlier age at menarche, with estimates per interquartile fold change in 5OH-MEHP ranging from -0.34 to -0.12 years in the different models. Findings from this study indicated associations between age at menarche and some specific EDCs at concentrations detected in the general European population, but due to the study design (menarche onset preceded the chemical measurements), caution is needed in the interpretation of causality. © 2023 by the authorsen
dc.format.extent1 Online-Resource (17 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1099
dc.identifier.urihttps://openumwelt.de/handle/123456789/1649
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectDINCH
dc.titlePFAS and Phthalate/DINCH exposure in association with age at menarche in teenagers of the HBM4EU aligned studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics11080711
local.bibliographicCitation.volume11 (2023), Heft 8
local.collectionAufsätze
local.contributor.authorId02192823
local.contributor.authorId02192824
local.contributor.authorId02191304
local.contributor.authorId02188720
local.identifier.catalogId02500766
local.ingest.leader05608naa a2200000uu 4500
local.jointTitlePFAS AND PHTHALATEDINCH EXPOSURE IN ASSOCIATION WITH AGE AT MENARCHE IN TEENAGERS OF THE HBM4EU ALIGNED STUDIES
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
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relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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