Publikation:
Parabens in urine of children and adolescents in Germany - human biomonitoring results of the german environmental survey 2014-2017 (GerES V)

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dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorTschersich, Carolin
dc.contributor.authorMurawski, Aline
dc.contributor.authorRucic, Enrico
dc.contributor.authorSchwedler, Gerda
dc.date.accessioned2024-06-16T13:58:36Z
dc.date.available2024-06-16T13:58:36Z
dc.date.issued2020
dc.description.abstractParabens are antimicrobial preservatives used in a wide range of consumer products such as personal care products, cosmetics, pharmaceuticals, and food. Consequently, the general population is ubiquitously exposed to these substances via dermal absorption, ingestion, and inhalation. Parabens promote estrogenic activity and are hence under assessment as endocrine disrupting substances. Urine samples from 3- to 17-year-old children and adolescents (N = 516) living in Germany were analysed for concentrations of nine parabens in the population representative German Environmental Survey for Children and Adolescents 2014-2017 (GerES V). Detection rates and urinary concentrations of the parabens decreased with increasing length of the alkyl chain. Methyl paraben was quantified in 97% of the samples with a geometric mean (GM) concentration of 7.724 (my)g/L (6.714 (my)g/gcreatinine), ethyl paraben was quantified in 69% (GM: 0.943 (my)g/L and 0.825 (my)g/gcrea), and n-propyl paraben in 31% (GM: 0.563 (my)g/L and 0.493 (my)g/gcrea). Concentrations of iso-propyl paraben, butyl paraben, iso-butyl paraben, and benzyl paraben were below the limit of quantification in most samples. Pentyl paraben and heptyl paraben were not detected in any of the samples. Paraben concentrations in urine were found to be associated with frequent usage of leave-on personal care products and cosmetics. Cumulative exposure to parabens (back-calculated daily intakes, expressed as hazard index) was found to be on a level raising concern in up to 14% of the population, mainly driven by n-propyl paraben, and depending on the level of conservativeness and point-of departures used for calculation. © 2020 The Author(s)en
dc.format.extent1 Onlineresource (8 pages)
dc.format.extent485,36 KB
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1065
dc.identifier.urihttps://openumwelt.de/handle/123456789/3970
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectEndokrin wirksame Substanz
dc.subjectExposition
dc.titleParabens in urine of children and adolescents in Germany - human biomonitoring results of the german environmental survey 2014-2017 (GerES V)
dc.title.alternativeParabens in urine of children and adolescents in Germany
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Research
local.bibliographicCitation.originalDOI10.1016/j.envres.2020.110502
local.bibliographicCitation.volume(2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)1164813641
local.contributor.authorId(DE-588)109109649X
local.contributor.authorId02186029
local.identifier.catalogId02479460
local.ingest.leader05916naa a2200000uu 4500
local.jointTitlePARABENS IN URINE OF CHILDREN AND ADOLESCENTS IN GERMANY HUMAN BIOMONITORING RESULTS OF THE GERMAN ENVIRONMENTAL SURVEY 20142017 GERES V
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