Publikation:
An ecotoxicological view on neurotoxicity assessment

Kurzanzeige
dc.contributor.authorLegradi, J. B.
dc.contributor.authorPaolo, C. Di
dc.contributor.authorKuckelkorn, Jochen
dc.contributor.authorKraak, M. H. S.
dc.contributor.otherGrummt, Tamara
dc.date.accessioned2024-06-16T14:57:23Z
dc.date.available2024-06-16T14:57:23Z
dc.date.issued2018
dc.description.abstractThe numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems. Quelle: Verlagsinformationen
dc.format.extent1 Onlineressource
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-1064
dc.identifier.urihttps://openumwelt.de/handle/123456789/5698
dc.identifier.urnurn:nbn:de:101:1-2019011921501411594548
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectNeurotoxizität
dc.subjectREACH-System
dc.subjectÖkologie
dc.subjectArt [Spezies]
dc.titleAn ecotoxicological view on neurotoxicity assessment
dc.title.alternativeAn ecotoxicological view on neurotoxicity assessment
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Sciences Europe
local.bibliographicCitation.originalDOI10.1186/s12302-018-0173-x
local.bibliographicCitation.volume30 (2018), Heft 1, 34 Seiten
local.collectionAufsätze
local.contributor.authorId02181632
local.contributor.authorId02181633
local.contributor.authorId02181634
local.contributor.otherId00289184
local.identifier.catalogId02463353
local.ingest.leader06592naa a2200000uu 4500
local.jointTitleAN ECOTOXICOLOGICAL VIEW ON NEUROTOXICITY ASSESSMENT
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