Publikation:
Development of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure

Kurzanzeige
dc.contributor.authorJunker, Thomas
dc.contributor.authorAtorf, Cornelia
dc.contributor.authorBerkner, Silvia
dc.contributor.authorKonradi, Sabine
dc.date.accessioned2024-06-16T14:03:31Z
dc.date.available2024-06-16T14:03:31Z
dc.date.issued2020
dc.description.abstractBackground Spreading of manure on agricultural soils represents an important pathway by which veterinary medicinal and biocidal products enter the environment. To assess their environmental impact in the context of authorization processes, experimental testing of transformation of these compounds in manure is considered in regulatory guidance documents. However, there is no standardized experimental test method available so far. To fill this gap, an experimental test method was developed to examine transformation in liquid cattle and pig manure. Results To account for manure specifics and for a possible influence of manure parameters on transformation rates, a comprehensive data acquisition and statistical analysis were performed. To address the variability of liquid manure of different type and origin, 30 manures were sampled and characterized. Thereof, three cattle and three pig manures were selected to perform anaerobic transformation studies with two radiolabeled veterinary medicinal active substances (14C-salicylic acid and 14C-paracetamol) and a confidential radiolabeled "14C-biocide B" serving as test compounds. Spatial and seasonal variability of manure parameters was quantified, and a sampling technique to obtain homogenous manure samples was developed. Transformation studies with six replicates per sampling point were conducted to examine the influence of test setup, of manure storage conditions, and of parameter variations between manure of the same species and of different species on half-lives, formation of extractable and non-extractable residues and mineralization rates. Finally, a test design was established that yields reproducible results for transformation studies in liquid cattle and pig manure under anaerobic conditions. Conclusions Results give a reliable basis for an experimental test method to perform anaerobic transformation studies in liquid cattle and pig manure. The developed test method comprises detailed guidance on selection of sampling date and site, collection from manure tank, storage duration and temperature in the laboratory, duration of manure acclimation period, and the incubation system design. It proved to give reproducible results in a validation ring test performed in a follow-up project and is planned to be submitted as draft test guideline for approval by the OECD. © The Author(s) 2020.en
dc.format.extent1 Onlineressource (21 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-978
dc.identifier.urihttps://openumwelt.de/handle/123456789/4127
dc.language.isoger
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectDung
dc.subjectTierarzneimittel
dc.subjectArzneimittel
dc.subjectBiozid
dc.subjectAbbau
dc.titleDevelopment of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure
dc.title.alternativeDevelopment of a test method for transformation of veterinary pharmaceuticals and biocides in anaerobic liquid manure
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Sciences Europe
local.bibliographicCitation.originalDOI10.1186/s12302-020-00323-8
local.bibliographicCitation.volume32 (2020)
local.collectionAufsätze
local.contributor.authorId00420021
local.contributor.authorId02170174
local.contributor.authorId02143078
local.contributor.authorId02163073
local.identifier.catalogId02477653
local.ingest.leader06752naa a2200000uu 4500
local.jointTitleDEVELOPMENT OF A TEST METHOD FOR TRANSFORMATION OF VETERINARY PHARMACEUTICALS AND BIOCIDES IN ANAEROBIC LIQUID MANURE
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
Dateien
Sammlungen
Aufsätze